Document Detail

Once daily sublingual immunotherapy without updosing--A new treatment schedule.
MedLine Citation:
PMID:  16741368     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Treatment regimens with specific immunotherapy include updosing. Due to excellent tolerance of sublingual immunotherapy (SLIT), it was hypothesized that administration of once-daily SLIT could be initiated safely without updosing. The objective was to evaluate tolerability of SLIT administered once daily without updosing. METHODS: 135 patients suffering from allergic rhinitis with/without asthma were included in a double-blind, placebo-controlled, parallel-group study. Patients were randomized into two groups. Group 1 (n = 69) received active treatment throughout the study, including 10 days updosing (T1), 20 days maintenance treatment (T2), and 2 consecutive months on maintenance treatment (T3 and T4). Group 2 (n = 66) obtained placebo updosing (T1), placebo maintenance (T2), initiated active treatment (maintenance) at T3, and continued active treatment until the end of the study (T4). Adverse events (AEs) were assessed at T1-T4. 66 grass- and 69 mite-allergic patients were evenly distributed between groups. RESULTS: 229 AEs were reported, 157 AEs were related to treatment. The most frequently reported AEs (>5% of patients in any group) related to treatment were oral itching, ocular itching, rhinitis, and sublingual edema. For group 1 at T2, the rate of all AEs related to treatment per dose administered was 1.79%, and for group 2 at T3 the rate was 1.33% (p = 0.37). For the most frequently reported AE, oral itching, the rate per dose administered was 1.01% for group 1 at T2, and 0.74% for group 2 at T3 (p = 0.53). CONCLUSIONS: Once daily SLIT was well tolerated and can be safely initiated without updosing.
F Rodriguez; M Boquete; M D Ibáñez; F de la Torre-Martínez; A I Tabar
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2006-06-02
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  140     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-09-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Hospital Marques de Valdecilla, Santander, Spain.
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MeSH Terms
Administration, Sublingual
Antigens, Dermatophagoides / administration & dosage,  therapeutic use*
Double-Blind Method
Drug Administration Schedule
Immunotherapy, Active / adverse effects,  methods*
Middle Aged
Plant Extracts / administration & dosage,  therapeutic use*
Poaceae / chemistry
Rhinitis / therapy*
Rhinitis, Allergic, Perennial / therapy
Rhinitis, Allergic, Seasonal / therapy
Treatment Outcome
Reg. No./Substance:
0/Antigens, Dermatophagoides; 0/Plant Extracts

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