| Once-daily intrapleural urokinase treatment of complicated parapneumonic effusion in pediatric patients. | |
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MedLine Citation:
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PMID: 20718185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this paper, we describe our experience in the treatment of childhood empyema using urokinase. Patients' ages ranged from 2 to 12 years. Urokinase (dosage: 3,100 IU/kg/day) was diluted in normal saline to produce 1000 IU/ml (maximum dosage 100,000 IU in 100 ml of normal saline). After 2 hours, the clamped catheters were released and connected to water-seal suction at a negative pressure of 10 cm H2O. Pleural irrigations were continued once a day until thoracostomy tube output decreased to less than 10 ml/day (urokinase treatment mean duration: 11.5 days). The complete resolution of the chest effusion was assessed on chest ultrasound scan and radiographs. None of the patients experienced any side effects due to urokinase. It would now seem reasonable to advocate small chest tube thoracostomy and intrapleural urokinase as first-line treatment of pleural empyema in children, with surgery indicated as a secondary intervention. |
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Authors:
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Maria Anastasia Bianchini; Pier Luca Ceccarelli; Paolo Repetto; Viviana Durante; Diego Biondini; Barbara Bergamini; Alfredo Cacciari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Turkish journal of pediatrics Volume: 52 ISSN: 0041-4301 ISO Abbreviation: Turk. J. Pediatr. Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417505 Medline TA: Turk J Pediatr Country: Turkey |
Other Details:
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Languages: eng Pagination: 274-7 Citation Subset: IM |
Affiliation:
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Departments of Pediatric Surgery, Azienda Universitaria Ospedaliera Policlinico di Modena, Modena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Female Humans Instillation, Drug Male Pleural Effusion / drug therapy*, radiography, ultrasonography Tomography, X-Ray Computed Urokinase-Type Plasminogen Activator / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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