| Once-daily inhaled glucocorticosteroid administration in controlled asthma patients. | |
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MedLine Citation:
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PMID: 18479954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inhaled glucocorticosteroids are usually administered in two equal daily doses. To simplify the method of treatment, once-daily administration has been used. However, little information regarding whether once-daily treatment can sufficiently control airway inflammation is available. We aimed to investigate whether once-daily administration of inhaled glucocorticosteroids can control airway inflammation. METHODS: Twenty-four well-controlled asthma patients were enrolled in a randomized crossover trial to compare the efficacies of once-daily and twice-daily administration of inhaled glucocorticosteroids. Initially, the patients were randomly assigned to receive either once-daily or twice-daily administration for 16 weeks. After an 8-week washout period, patients who originally received twice-daily administration were assigned to once-daily administration for 16 weeks and vice versa. We assessed the changes in the forced expiratory volume in 1s, morning and evening peak expiratory flows, asthma symptoms, health-related quality of life and fractional exhaled nitric oxide levels. RESULTS: Patients with once-daily administration showed the same level of clinical control and lung functions as patients receiving twice-daily administration. There was no difference in the fractional exhaled nitric oxide levels between the beginning and end of the twice-daily treatment (35.69 and 33.23ppb, respectively). In contrast, the fractional exhaled nitric oxide level was significantly higher at the end of the once-daily treatment (33.87 and 39.38ppb, respectively, p< 0.001). CONCLUSION: Although once-daily administration is sufficient for clinical control of asthma, it might not control airway inflammation sufficiently. |
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Authors:
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Hirotsugu Hasegawa; Naoki Inui; Tomoyuki Fujisawa; Jun Sato; Hirotoshi Nakamura; Hiroshi Watanabe; Takafumi Suda; Kingo Chida |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-03-29 |
Journal Detail:
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Title: Pulmonary pharmacology & therapeutics Volume: 21 ISSN: 1094-5539 ISO Abbreviation: Pulm Pharmacol Ther Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9715279 Medline TA: Pulm Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 663-7 Citation Subset: IM |
Affiliation:
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The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Aged Asthma / drug therapy* Beclomethasone / administration & dosage, therapeutic use* Breath Tests Budesonide / administration & dosage, therapeutic use Cross-Over Studies Drug Administration Schedule Female Forced Expiratory Volume / drug effects Glucocorticoids / administration & dosage, therapeutic use* Humans Male Middle Aged Nitric Oxide / metabolism* Quality of Life |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 10102-43-9/Nitric Oxide; 4419-39-0/Beclomethasone; 51333-22-3/Budesonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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