Document Detail

Once daily administration of a fluphenazine/nortriptyline preparation in the treatment of mixed anxiety/depressive states.
MedLine Citation:
PMID:  795608     Owner:  NLM     Status:  MEDLINE    
A study of 223 patients diagnosed as suffering from mixed anxiety/depressive states was carried out in general practice to compare the effectiveness of treatment with a once-daily tablet preparation containing 1.5 mg fluphenazine plus 30 mg nortriptyline, taken either at night or in the morning, with the same total daily dose taken as 1 tablet t.d.s. Patients were randomly assigned to 4-week's treatment with one of the three drug schemes, and patients' self-ratings as well as physicians's ratings were used to assess symptoms. Both rating assessments showed that there were highly significant improvements in each of the three treatment groups over the 4-week period. Although there were no clinically important differences between improvements in the night-time dose and t.d.s. groups, there was a higher incidence of drowsiness and tablet defaulting among patients taking the single morning dose.
N H Brodie; R L McGhie; H O'Hara; J O'Hara; A E Rodway; J C Valle-Jones; A A Schiff
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Current medical research and opinion     Volume:  4     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1976  
Date Detail:
Created Date:  1977-03-21     Completed Date:  1977-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  346-52     Citation Subset:  IM    
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MeSH Terms
Adjustment Disorders / drug therapy*
Anxiety Disorders / drug therapy*
Clinical Trials as Topic
Drug Administration Schedule
Drug Combinations
Fluphenazine / administration & dosage*,  adverse effects
Middle Aged
Nortriptyline / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Drug Combinations; 69-23-8/Fluphenazine; 72-69-5/Nortriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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