Document Detail

Omphalocele and gastroschisis in the State of New York, 1992-1999.
MedLine Citation:
PMID:  14703785     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Variations in the temporal distribution and risk factors for omphalocele and gastroschisis have been suggested although results have not been conclusive. This study examines the trend and risk factors for both conditions among live births in New York State. METHODS: Analysis of surveillance data from the New York Congenital Malformation Registry for the years 1992-1999. RESULTS: Five hundred and ninety-five (595) infants with either omphalocele (287) or gastroschisis (308) were identified. It appeared that the prevalence of gastroschisis was rising from 1992-1999, while prevalence of omphalocele was decreasing. Cases of gastroschisis were clustered among younger mothers while the maternal age distribution among omphalocele infants was U-shaped. As compared to Whites, Black infants were more likely to present with omphalocele (OR = 1.73; 95% confidence interval = 1.28-2.33) and Hispanic infants with gastroschisis (OR = 1.50; 95% CI = 1.12-2.00). For both anomalies, residents of rural New York were significantly at higher risk than those living in urban New York. Twenty-three chromosomal aberrations were detected, all among omphalocele babies. Infant survival was substantially greater among gastroschisis (92%) as compared to omphalocele newborn (81%)[p < 0.0001]. CONCLUSIONS: Prevalence of gastroschisis has been on the rise while that of omphalocele has been declining in New York State. Geographical and racial/ethnic variations were observed, further confirming the notion of different etiologies for the two congenital anomalies.
Hamisu M Salihu; Bosny J Pierre-Louis; Charlotte M Druschel; Russell S Kirby
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  67     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2004-01-05     Completed Date:  2004-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  630-6     Citation Subset:  IM    
Department of Maternal and Child Health, University of Alabama at Birmingham, Alabama 35294, USA.
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MeSH Terms
African Continental Ancestry Group
Chromosome Aberrations
Confidence Intervals
European Continental Ancestry Group
Gastroschisis / diagnosis,  epidemiology*,  ethnology
Hernia, Umbilical / diagnosis,  epidemiology*,  ethnology
Hispanic Americans
Infant, Newborn
Maternal Age
Medical Record Linkage
New York / epidemiology
Odds Ratio
Pregnancy Outcome
Retrospective Studies
Rural Population
Sex Ratio

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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