Document Detail


Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) in triplet pregnancy after IVF and CVS.
MedLine Citation:
PMID:  12962293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex is a rare sporadic condition. CASE: We identified an infant with major malformations resembling OEIS. He was the product of a 30-week triplet pregnancy conceived by in vitro fertilization (IVF) and evaluated by chorionic villi sampling (CVS). In this article, we review the possible pathogenetic mechanisms in this case, including IVF, multiple gestation, trauma to the uterus or uterine vessels following CVS, and placenta accreta. CONCLUSIONS: We conclude that the cumulative effects of all or some of these factors may have resulted in uteroplacental insufficiency adequate to produce this phenotype. This case provides additional evidence for the uterine vascular pathogenesis of OEIS complex in humans.
Authors:
Alan L Shanske; Sumati Pande; Karim Aref; Carlos Vega-Rich; Luc Brion; Sandra Reznik; Ilan E Timor-Tritsch
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  67     ISSN:  1542-0752     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-09-09     Completed Date:  2004-02-04     Revised Date:  2004-12-15    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-71     Citation Subset:  IM    
Affiliation:
Center for Congenital Disorders, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York 10467, USA. Ashanske@AOL.com
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / embryology,  etiology*,  pathology
Anus, Imperforate / embryology,  etiology*,  pathology
Bladder Exstrophy / embryology,  etiology*,  pathology
Chorionic Villi Sampling
Female
Fertilization in Vitro
Hernia, Umbilical / embryology,  etiology*,  pathology
Humans
Infant, Newborn
Male
Maternal Age
Pregnancy
Pregnancy, High-Risk
Spinal Dysraphism / embryology,  etiology*,  pathology
Triplets*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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