| Omphalocele, advanced maternal age, and fetal morbidity outcomes. | |
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MedLine Citation:
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PMID: 15887299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we wanted to determine if the risk for adverse neonatal outcome among omphalocele-affected fetuses is increased among older gravidas. This was a retrospective cohort study on live-born infants with omphalocele delivered in New York State from 1983 through 1999. We compared infants of older (>or=35 years) with those of younger (<35 years) mothers with respect to the following fetal morbidity indices: low birth weight and very low birth weight, preterm and very preterm, and small for gestational age. We used adjusted odds ratios to approximate relative risks. Data on a total of 1,010 infants with omphalocele were analyzed. Mean gestational age and birth weight were similar in both maternal age categories: mean+/-standard deviation (SD) for infants with omphalocele born to older mothers=37.4 weeks+/-3.9 versus 38.0 weeks+/-5.1 for those of younger mothers (P=0.2); mean birth weights+/-SD for infants with omphalocele born to older mothers=2,813+/-871.1 versus 2,958+/-809.9 for those of younger mothers (P=0.08). Also, the two maternal age sub-groups did not differ with respect to the fetal morbidity outcome: low birth weight (OR=0.95; 95% CI=0.60-1.51), very low birth weight (OR=0.78; 95% CI=0.36-1.69), preterm (OR=0.95; 95% CI=0.58-1.57), very preterm (OR=0.73; 95% CI=0.34-1.58), and SGA (OR=1.00; 95% CI=0.44-2.27). Thus, advanced maternal age does not appear to be a risk factor for fetal morbidity outcomes among omphalocele-affected fetuses. This information is potentially useful in counseling affected parents. |
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Authors:
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Hamisu M Salihu; Donath Emusu; Zakari Y Aliyu; Bosny J Pierre-Louis; Charlotte M Druschel; Russell S Kirby |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of medical genetics. Part A Volume: 135 ISSN: 1552-4825 ISO Abbreviation: Am. J. Med. Genet. A Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-26 Completed Date: 2005-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101235741 Medline TA: Am J Med Genet A Country: United States |
Other Details:
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Languages: eng Pagination: 161-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 Wiley-Liss, Inc. |
Affiliation:
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Department of Maternal and Child Health, University of Alabama, Birmingham, Alabama 35294, USA. hsalihu@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Cohort Studies Female Fetal Weight Hernia, Umbilical / epidemiology*, physiopathology Humans Infant, Newborn Maternal Age* Morbidity New York / epidemiology Pregnancy Pregnancy Outcome Retrospective Studies Risk Factors |
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