Document Detail


Omni-Stat(®) (Chitosan) arrests bleeding in heparinised subjects in vivo: an experimental study in a model of major peripheral vascular injury.
MedLine Citation:
PMID:  21055962     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: To explore the effectiveness of Omni-Stat(®) (Chitosan) in a model of major haemorrhage in the presence of clotting dysfunction. Method: A total of 12 major femoral artery bleeds in moderately heparinised swine treated with Omni-Stat(®) (Chitosan) were compared with five control bleeds. Results: Haemostasis was successfully achieved at first treatment in 10 of 12 bleeds and at second treatment in the remaining two bleeds. Conclusion: The study supports the evidence that Omni-Stat(®) (Chitosan) acts independently of classical clotting pathways and should be effective in patients with clotting dysfunctions, who suffer major haemorrhage. It also suggests the potential for a role in cardiac surgery.
Authors:
Russell W J Millner; Alan S Lockhart; Rebecca Marr; Keith Jones
Publication Detail:
Type:  Journal Article     Date:  2010-11-04
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  39     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  952-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Cardiothoracic Surgery, Blackpool Victoria Hospital Whinney Heys Road, Blackpool, FY3 8NR, UK.
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