| Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity. | |
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MedLine Citation:
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PMID: 15273128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. The omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity. |
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Authors:
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Helio S Sader; Kelley A Fedler; Robert P Rennie; Shelley Stevens; Ronald N Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 48 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-26 Completed Date: 2004-09-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 3112-8 Citation Subset: IM |
Affiliation:
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The Jones Group/JMI Laboratories, Inc., North Liberty, Iowa 52317, USA. helio-sader@jmilabs.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology* Antimicrobial Cationic Peptides / pharmacology* Bacteria / drug effects* Bacterial Infections / microbiology Candida / drug effects Candidiasis / microbiology Colony Count, Microbial Drug Stability Freezing Humans Kinetics Microbial Sensitivity Tests Oxacillin / pharmacology Penicillin Resistance Penicillins / pharmacology Vancomycin Resistance |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Penicillins; 0/omiganan pentahydrochloride; 66-79-5/Oxacillin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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