Document Detail

Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity.
MedLine Citation:
PMID:  15273128     Owner:  NLM     Status:  MEDLINE    
The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. The omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
Helio S Sader; Kelley A Fedler; Robert P Rennie; Shelley Stevens; Ronald N Jones
Related Documents :
20625158 - Purification and characterization of avian beta-defensin 11, an antimicrobial peptide o...
20865718 - Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial a...
9699208 - A protein kinase inhibitor from a431 subline overexpressing tgf alpha possesses antimic...
22411928 - Elastin degradation is associated with progressive aortic stiffening and all-cause mort...
7190838 - Structural studies on histones h1. circular dichroism and difference spectroscopy of th...
24947668 - Tyrosinase-catalyzed site-specific immobilization of engineered c-phycocyanin to surface.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  48     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-26     Completed Date:  2004-09-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3112-8     Citation Subset:  IM    
The Jones Group/JMI Laboratories, Inc., North Liberty, Iowa 52317, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Bacterial Agents / pharmacology*
Antimicrobial Cationic Peptides / pharmacology*
Bacteria / drug effects*
Bacterial Infections / microbiology
Candida / drug effects
Candidiasis / microbiology
Colony Count, Microbial
Drug Stability
Microbial Sensitivity Tests
Oxacillin / pharmacology
Penicillin Resistance
Penicillins / pharmacology
Vancomycin Resistance
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Penicillins; 0/omiganan pentahydrochloride; 66-79-5/Oxacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant o...
Next Document:  Inhibitory activities of colicins against Escherichia coli strains responsible for postweaning diarr...