Document Detail


Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity.
MedLine Citation:
PMID:  15273128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. The omiganan was highly active, and minimal bactericidal concentrations or minimal fungicidal concentrations were either equal to or two- to fourfold higher than MICs. Kill curve experiments showed a clear pattern of bactericidal activity.
Authors:
Helio S Sader; Kelley A Fedler; Robert P Rennie; Shelley Stevens; Ronald N Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  48     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-26     Completed Date:  2004-09-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3112-8     Citation Subset:  IM    
Affiliation:
The Jones Group/JMI Laboratories, Inc., North Liberty, Iowa 52317, USA. helio-sader@jmilabs.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Antimicrobial Cationic Peptides / pharmacology*
Bacteria / drug effects*
Bacterial Infections / microbiology
Candida / drug effects
Candidiasis / microbiology
Colony Count, Microbial
Drug Stability
Freezing
Humans
Kinetics
Microbial Sensitivity Tests
Oxacillin / pharmacology
Penicillin Resistance
Penicillins / pharmacology
Vancomycin Resistance
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Penicillins; 0/omiganan pentahydrochloride; 66-79-5/Oxacillin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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