Document Detail


Omeprazole versus famotidine in the healing and relapse of duodenal ulcer.
MedLine Citation:
PMID:  8218758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty patients with symptomatic duodenal ulcer were randomized to receive either omeprazole (20 mg each morning) or famotidine (40 mg at night time) for 2-4 weeks in a double-blind parallel group clinical trial. Healing rates were higher with omeprazole in comparison with famotidine after 2 weeks (77% vs. 40%, P < 0.001) and 4 weeks (93% vs. 80%, P = 0.2) of treatment. Assessment of daily diary cards completed by all patients revealed that omeprazole rapidly relieved ulcer-related day pain and nocturnal pain in comparison to famotidine. Treatment with omeprazole for 2 weeks was also associated with lower cumulative antacid intake (P < 0.05) and reduced absenteeism from work. Helicobacter pylori infection was present in all patients and remained unaffected by treatment with either of the drugs. None of the drugs produced any significant adverse effects. During 6 months follow-up of all the patients after ulcer healing (without maintenance therapy), ulcer relapse was seen in 40% of omeprazole- and 37% of famotidine-treated patients (P > 0.1). The duration of ulcer-free period following initial healing of ulcer was also similar in both the groups (median time: 22 weeks for omeprazole, 21 weeks for famotidine). We conclude that omeprazole is superior to famotidine in rapidly healing duodenal ulcers and achieving more rapid pain relief, but does not influence subsequent ulcer relapse.
Authors:
S C Misra; S Dasarathy; M P Sharma
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  7     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-10     Completed Date:  1993-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  443-9     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Descriptor/Qualifier:
Absenteeism
Adult
Analgesics / therapeutic use
Antacids / administration & dosage
Double-Blind Method
Duodenal Ulcer / drug therapy*,  microbiology,  physiopathology
Famotidine / adverse effects,  therapeutic use*
Female
Helicobacter Infections / diagnosis
Helicobacter pylori
Humans
Male
Middle Aged
Omeprazole / adverse effects,  therapeutic use*
Pain / prevention & control
Recurrence
Wound Healing / drug effects*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Antacids; 73590-58-6/Omeprazole; 76824-35-6/Famotidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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