| Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12) | |
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MedLine Citation:
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PMID: 8273984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate protein-bound cyanocobalamin (vitamin B12) absorption before and after omeprazole (Prilosec) therapy in healthy male volunteers. DESIGN: Clinical trial in which each volunteer served as his own control. SETTING: Outpatient department of a university medical center. PARTICIPANTS: Ten healthy, male volunteers 22 to 50 years old. INTERVENTION: Each participant had a modified Schilling test (protein-bound cyanocobalamin) and a gastric analysis, as well as measurements of serum vitamin B12, gastrin, and folate levels. Five patients were then randomly assigned to take either 20 mg or 40 mg of omeprazole daily. After 2 weeks of omeprazole therapy, these tests were repeated. MEASUREMENTS: The modified Schilling test, gastric analysis, serum gastrin level, folate level, and cyanocobalamin level. RESULTS: At the end of the 2-week treatment period, cyanocobalamin absorption decreased from 3.2% to 0.9% (P = 0.031) in participants receiving 20 mg of omeprazole daily. In patients taking 40 mg of omeprazole daily, cyanocobalamin absorption decreased from 3.4% to 0.4% (P < 0.05). CONCLUSIONS: Omeprazole therapy acutely decreased cyanocobalamin absorption in a dose-dependent manner. |
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Authors:
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S P Marcuard; L Albernaz; P G Khazanie |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of internal medicine Volume: 120 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-02-01 Completed Date: 1994-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 211-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, East Carolina University School of Medicine, Greenville, NC 287858-4354. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Malabsorption Syndromes / blood, chemically induced* Male Middle Aged Omeprazole / adverse effects* Protein Binding Reference Values Vitamin B 12 / blood* Vitamin B 12 Deficiency / chemically induced |
| Chemical | |
Reg. No./Substance:
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68-19-9/Vitamin B 12; 73590-58-6/Omeprazole |
| Comments/Corrections | |
Comment In:
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Ann Intern Med. 1994 Jul 1;121(1):74
[PMID:
8198354
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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