| Omeprazole and regulation of cytokine profile in Helicobacter pylori-infected patients with duodenal ulcer disease. | |
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MedLine Citation:
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PMID: 11100337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: To estimate the cytokine profile in Helicobacter pylori-positive patients with duodenal ulcers treated with omeprazole. METHODOLOGY: The subjects were 22 patients with endoscopically defined active duodenal ulcers and H. pylori infection treated with omeprazole for 3 months after initial 1-week triple therapy. Peripheral blood CD3+ CD4+ and CD8+ T lymphocytes, percentage of HLA-DR+ peripheral blood lymphocytes, and cytokine levels (GM-CSF, IL-6 and IL-2) were measured in the supernatants from PHA-cultured peripheral blood lymphocytes at baseline conditions and after 3-months' omeprazole treatment. RESULTS: The H. pylori eradication triple regimen cured H. pylori infection in 86.4% of our patients. Peripheral blood CD3+ CD4+ and CD8+ T lymphocytes were not affected by omeprazole treatment (P > 0.05), whereas the percentage of HLA-DR+ peripheral blood lymphocytes increased significantly post-treatment (P < 0.05). All cytokine levels measured in the supernatants showed a significant decrease after treatment (P < 0.001). CONCLUSIONS: The significant decrease in the two pro-inflammatory cytokines (GM-CSF, IL-6) and the major inflammatory cytokine IL-2, implies that the potential cytokine synthesis of the Th1 pattern from peripheral blood lymphocytes is highly suppressed after treatment. This effect on cytokine regulation seems to be a result of the positive H. pylori infection outcome at the immunological level, which leads to "normalization" of cytokine production. |
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Authors:
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J Kountouras; P Boura; N J Lygidakis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 47 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2000 Sep-Oct |
Date Detail:
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Created Date: 2001-03-29 Completed Date: 2001-05-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: GREECE |
Other Details:
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Languages: eng Pagination: 1301-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, Greece. jannis@med.auth.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Ulcer Agents
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pharmacology,
therapeutic use* Duodenal Ulcer / complications, drug therapy*, immunology* Female Granulocyte-Macrophage Colony-Stimulating Factor / blood* Helicobacter Infections / complications, drug therapy*, immunology* Helicobacter pylori* Humans Interleukin-2 / blood* Interleukin-6 / blood* Male Middle Aged Omeprazole / pharmacology, therapeutic use* T-Lymphocyte Subsets / immunology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Interleukin-2; 0/Interleukin-6; 73590-58-6/Omeprazole; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
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