| Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux. | |
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MedLine Citation:
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PMID: 17354108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the relationships between airway responsiveness to methacholine and capsaicin, proximal or distal reflux and the effects of short-term acid inhibition. MATERIAL AND METHODS: Twenty-nine asthmatics, not taking steroids regularly, underwent respiratory symptom measurements, 24-h dual-probe pH monitoring, and challenges with methacholine and capsaicin. Challenges and symptom measurements were repeated after 12 days' omeprazole treatment (20 mg b.i.d.). The results (median and range) were expressed as PD20 methacholine (mg) and PD5 capsaicin (dose causing five coughs, nmol). RESULTS: Seventeen patients presented pathological reflux in the distal esophagus, and 17 in the proximal esophagus. At baseline no correlation was found between PD20 or PD5 and reflux. Treatment with omeprazole did not change bronchial responsiveness to methacholine (basal: 0.16 mg, 0.02-1.27; omeprazole: 0.15 mg, 0.02-1.60); omeprazole decreased the tussive response to capsaicin (basal: 0.08 nmol, 0.08-2.46; omeprazole: 0.61 nmol, 0.08-9.84, p<0.001) only in patients with pathological reflux. The decrease was positively correlated with proximal acid exposure (r2=0.70, p<0.001). Omeprazole reduced asthma symptoms in patients with proximal reflux, cough in those with proximal or distal reflux. CONCLUSIONS: In asthmatics, inhibition of gastric acid secretion does not influence bronchial hyperresponsiveness but decreases tussive sensitivity and this effect is related to proximal reflux. |
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Authors:
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Marcello Ferrari; Luigi Benini; Emanuele Brotto; Francesca Locatelli; Fosca De Iorio; Francesco Bonella; Naika Tacchella; Giuliano Corradini; Vincenzo Lo Cascio; Italo Vantini |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 42 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-13 Completed Date: 2007-08-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
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Languages: eng Pagination: 299-307 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Biomediche e Chirurgiche, Università di Verona, Italy. marcello.ferrari@univr.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance / drug effects Analgesics, Non-Narcotic / diagnostic use* Anti-Ulcer Agents / therapeutic use* Asthma / etiology, physiopathology* Bronchial Hyperreactivity / etiology, physiopathology Bronchial Provocation Tests Bronchoconstriction / drug effects Bronchoconstrictor Agents / diagnostic use* Capsaicin / diagnostic use* Esophageal pH Monitoring Female Forced Expiratory Volume / drug effects Gastroesophageal Reflux / complications, drug therapy*, physiopathology Humans Hydrogen-Ion Concentration / drug effects Male Methacholine Chloride / diagnostic use* Middle Aged Omeprazole / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 0/Anti-Ulcer Agents; 0/Bronchoconstrictor Agents; 404-86-4/Capsaicin; 62-51-1/Methacholine Chloride; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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