Document Detail

Omeprazole in the management of intractable esophageal ulceration following injection sclerotherapy.
MedLine Citation:
PMID:  2227299     Owner:  NLM     Status:  MEDLINE    
Transient esophageal ulceration is a common finding after sclerotherapy of varices. A small proportion of these ulcers become chronic and resistant to conventional therapy. Such chronic ulcers have been associated with pain, stricture formation, and recurrent hemorrhage. The use of omeprazole, a proton pump inhibitor, was examined in the current study in the treatment of 10 patients (6 women, 4 men; age range, 27-86 years) with cirrhosis (PBC, 4; sclerosing cholangitis, 2; chronic active liver disease, 2; alcohol, 1; and cryptogenic, 1) who developed an esophageal ulcer after a mean of 13 (range, 8-21) sessions of sclerotherapy. The ulcers had been present for 3-54 months despite prolonged treatment with high-dose H2-receptor antagonists and sucralfate. In each case one or more complications had occurred: severe pain in 3, stricture formation in 4, and recurrent hemorrhage in 7 cases. After an 8-week course of omeprazole, 40 mg daily, endoscopy confirmed complete healing of the ulceration in all 10 cases with symptom resolution. In 2 cases the ulcer recurred, with associated bleeding within 6 weeks of discontinuing the treatment in 1 patient. Both cases responded to repeat therapy. These results confirm the efficacy of omeprazole for postsclerotherapy ulceration and imply that acid-pepsin has a role in perpetuating such ulcers.
A Gimson; R Polson; D Westaby; R Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  99     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1990-12-12     Completed Date:  1990-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1829-31     Citation Subset:  AIM; IM    
Liver Unit, King's College Hospital, London, England.
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MeSH Terms
Aged, 80 and over
Esophageal Diseases / drug therapy*,  etiology
Follow-Up Studies
Middle Aged
Omeprazole / therapeutic use*
Sclerotherapy / adverse effects*
Ulcer / drug therapy*,  etiology
Varicose Veins / therapy
Reg. No./Substance:

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