Document Detail

Omeprazole and clopidogrel: Should clinicians be worried?
MedLine Citation:
PMID:  20124268     Owner:  NLM     Status:  MEDLINE    
The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor.
Jeremiah P Depta; Deepak L Bhatt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cleveland Clinic journal of medicine     Volume:  77     ISSN:  1939-2869     ISO Abbreviation:  Cleve Clin J Med     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703441     Medline TA:  Cleve Clin J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-6     Citation Subset:  IM    
Department of Internal Medicine, Medicine Institute, Cleveland Clinic, USA.
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MeSH Terms
Anti-Ulcer Agents / administration & dosage,  adverse effects*
Drug Interactions
Drug Therapy, Combination / adverse effects
Omeprazole / administration & dosage,  adverse effects*
Platelet Aggregation Inhibitors / administration & dosage,  adverse effects*
Ticlopidine / administration & dosage,  adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Platelet Aggregation Inhibitors; 55142-85-3/Ticlopidine; 73590-58-6/Omeprazole; 90055-48-4/clopidogrel

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