| Omeprazole and clopidogrel: Should clinicians be worried? | |
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MedLine Citation:
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PMID: 20124268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor. |
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Authors:
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Jeremiah P Depta; Deepak L Bhatt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cleveland Clinic journal of medicine Volume: 77 ISSN: 1939-2869 ISO Abbreviation: Cleve Clin J Med Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703441 Medline TA: Cleve Clin J Med Country: United States |
Other Details:
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Languages: eng Pagination: 113-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Medicine Institute, Cleveland Clinic, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Ulcer Agents
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administration & dosage,
adverse effects* Drug Interactions Drug Therapy, Combination / adverse effects Humans Omeprazole / administration & dosage, adverse effects* Platelet Aggregation Inhibitors / administration & dosage, adverse effects* Ticlopidine / administration & dosage, adverse effects, analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Platelet Aggregation Inhibitors; 55142-85-3/Ticlopidine; 73590-58-6/Omeprazole; 90055-48-4/clopidogrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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