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Omentin prevents myocardial ischemic injury through AMPK- and Akt-dependent mechanisms.
MedLine Citation:
PMID:  24768874     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: We examined the impacts of omentin on myocardial injury in a mouse model of ischemia/reperfusion (I/R), and explored its underlying mechanisms.
BACKGROUND: Obesity is a major risk factor for ischemic heart disease. Omentin is a circulating adipokine that is downregulated by obesity.
METHODS: In patients who underwent successful reperfusion treatment after acute myocardial infarction (AMI), cardiac function and perfusion defect were assessed by scintigraphic images. Mice were subjected to myocardial ischemia followed by reperfusion.
RESULTS: High levels of plasma omentin associated with improvement of heart damage and function after reperfusion therapy in patients with AMI. Systemic administration of human omentin to mice led to reduction of myocardial infarct size and apoptosis following I/R, which was accompanied by enhanced phosphorylation of AMP-activated protein kinase (AMPK) and Akt in the ischemic heart. Fat-specific overexpression of human omentin also resulted in reduction of infarct size after I/R. Blockade of AMPK or Akt activity reversed omentin-induced inhibition of myocardial ischemic damage and apoptosis in mice. In cultured cardiomyocytes, omentin suppressed hypoxia/reoxygenation-induced apoptosis, which was blocked by inactivation of AMPK or Akt.
CONCLUSIONS: Our data indicate that omentin functions as an adipokine that ameliorates acute ischemic injury in the heart by suppressing myocyte apoptosis through both AMPK- and Akt-dependent mechanisms.
Authors:
Yoshiyuki Kataoka; Rei Shibata; Koji Ohashi; Takahiro Kambara; Takashi Enomoto; Yusuke Uemura; Yasuhiro Ogura; Daisuke Yuasa; Kazuhiro Matsuo; Takanobu Nagata; Toyoharu Oba; Hideo Yasukawa; Yasushi Numaguchi; Takahito Sone; Toyoaki Murohara; Noriyuki Ouchi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-11
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  -     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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