| Omentin-1 and vaspin are present in the fetus and neonate, and perinatal concentrations are similar in normal and growth-restricted pregnancies. | |
| | |
MedLine Citation:
|
PMID: 20488498 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The aim of this study was to investigate circulating concentrations of omentin-1 and vaspin (adipocytokines predominantly secreted by visceral adipose tissue and not yet investigated in perinatal life) in maternal, fetal, and neonatal samples from intrauterine growth-restricted (IUGR; associated with altered development of adipose tissue) and appropriate-for-gestational-age (AGA) pregnancies and to correlate them with the respective insulin concentrations. Serum omentin-1 and vaspin concentrations were determined by enzyme immunoassay in 40 mothers and their 20 IUGR and 20 AGA singleton full-term fetuses and neonates on postnatal day 1 (N1) and day 4 (N4). Both hormones were detectable in fetal and neonatal blood (omentin-1 [mean ± SD, in nanograms per milliliter]: AGA vs IUGR group-fetal: 11.32 ± 1.88 vs 10.47 ± 1.30, N1: 10.74 ± 1.42 vs 10.46 ± 1.54, and N4: 10.90 ± 2.72 vs 11.35 ± 3.92; vaspin [median, minimum-maximum; in nanograms per milliliter]: AGA vs IUGR group-fetal: 0.39 [0.04-19.06] vs 0.40 [0.05-1.34], N1: 0.40 [0.04-16.70] vs 0.44 [0.23-3.34], and N4: 0.49 [0.02-8.89] vs 0.55 [0.06-3.92]). No significant differences in omentin-1 or vaspin concentrations were observed between IUGR and AGA groups, whereas fetal and N1 insulin concentrations were lower in the former (P = .025 and P = .027, respectively). In both groups, fetal omentin-1 concentrations were higher (P ≤ .018), whereas vaspin concentrations were lower (P ≤ .001), than maternal ones. Furthermore, maternal vaspin concentrations were higher in cases of cesarean delivery (P = .024). Omentin-1 and vaspin concentrations did not correlate with the respective insulin ones. In conclusion, omentin-1 and vaspin are present in the fetus and neonate. Perinatal concentrations of omentin-1 and vaspin are similar in IUGR cases and AGA controls-despite lower insulin concentrations in the former-and do not correlate with the respective insulin concentrations. Higher omentin-1 concentrations in the fetus may be crucial to enhance a growth-promoting effect, whereas lower maternal vaspin concentrations in cases of vaginal delivery may be attributed to spontaneous term delivery inflammation. |
| | |
Authors:
|
Despina D Briana; Maria Boutsikou; Stavroula Baka; Dimitrios Gourgiotis; Antonios Marmarinos; Sofia Liosi; Dimitrios Hassiakos; Ariadne Malamitsi-Puchner |
Related Documents
:
|
6379528 - Impaired fetal growth: definition and clinical diagnosis. 9926978 - Fetal growth in the baboon during the second half of pregnancy. 16612108 - The consequences of being born small - an adaptive perspective. 15265238 - Endometrial glands as a source of nutrients, growth factors and cytokines during the fi... 19438168 - Cesarean scar ectopic pregnancy in a patient with multiple prior cesarean sections: a c... 3281458 - Prenatal diagnosis of chromosome abnormalities in the presence of fetal structural defe... |
Publication Detail:
|
Type: Journal Article Date: 2010-05-20 |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 60 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
|
Languages: eng Pagination: 486-90 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, 10682 Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sediment profile characterisation at contaminated and reference locations in the Windmill Islands, E...
Next Document: Arabinogalactan-proteins from cell suspension cultures of Araucaria angustifolia.