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Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome.
MedLine Citation:
PMID:  21497934     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: The goal of this study was to investigate the association between omentin-1 and carotid atherosclerosis in patients with metabolic syndrome (MetS). METHOD: We enrolled randomly 60 MetS patients, evaluated their carotid atherosclerosis employing ultrasonography and then divided them into two subgroups, MetS with atherosclerosis (MetS+AS) and MetS without atherosclerosis (MetS-AS) according to the level of carotid intima-media thickness (CIMT) and presence of plaque. Stiffness, strain and distensibility were calculated. Waist circumference and blood pressure (BP) were measured. Fasting blood sample was collected to determine biochemical indicators and insulin resistance index (HOMA-IR). Omentin-1 plasma level was assessed by ELISA. Association of omentin-1 with CIMT and metabolic markers were studied. RESULTS: Levels of omentin-1 were lower in MetS than in controls and reduced further in MetS+AS compared with MetS-AS. In correlation analysis, omentin-1 was negative associated with CIMT, stiffness, waist circumference, body mass index (BMI), systolic blood pressure (SBP), fast blood glucose (FBG), and HOMA-IR. CONCLUSIONS: Omentin-1 is closely related to MetS and might play an important role in atherosclerosis in MetS patients.
Authors:
Rong Liu; Xiuling Wang; Peili Bu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-15
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  -     ISSN:  1872-8227     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital of Shandong University, 250012 Jinan, Shandong Province, China; Department of Cardiology, Qilu Hospital of Shandong University, 250012 Jinan, Shandong Province, China.
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