|Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons.|
|PMID: 17594339 Owner: NLM Status: MEDLINE|
|Pre-clinical studies suggest that both omega-6 and omega-3 fatty acids have beneficial effects on peripheral nerve function. Rats feed a diet rich in polyunsaturated fatty acids (PUFAs) showed modification of phospholipid fatty acid composition in nerve membranes and improvement of sciatic nerve conduction velocity (NCV). We tested the hypothesis that baseline plasma omega-6 and omega-3 fatty acids levels predict accelerated decline of peripheral nerve function. Changes between baseline and the 3-year follow-up in peripheral nerve function was assessed by standard surface ENG of the right peroneal nerve in 384 male and 443 female participants of the InCHIANTI study (age range: 24-97 years). Plasma concentrations of selected fatty acids assessed at baseline by gas chromatography. Independent of confounders, plasma omega-6 fatty acids and linoleic acid were significantly correlated with peroneal NCV at enrollment. Lower plasma PUFA, omega-6 fatty acids, linoleic acid, ratio omega-6/omega-3, arachidonic acid and docosahexanoic acid levels were significantly predicted a steeper decline in nerve function parameters over the 3-year follow-up. Low plasma omega-6 and omega-3 fatty acids levels were associated with accelerated decline of peripheral nerve function with aging.|
|F Lauretani; S Bandinelli; B Bartali; B Benedetta; A Cherubini; A D Iorio; A Blè; V Giacomini; A M Corsi; J M Guralnik; L Ferrucci|
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|Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't|
|Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 14 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2007 Jul|
|Created Date: 2007-06-27 Completed Date: 2007-08-15 Revised Date: 2013-06-06|
Medline Journal Info:
|Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England|
|Languages: eng Pagination: 801-8 Citation Subset: IM|
|Tuscany Regional Health Agency, Florence, Italy.|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Aging / physiology*
Arachidonic Acid / blood
Cholesterol / blood
Diabetes Mellitus / epidemiology
Docosahexaenoic Acids / blood
Eicosapentaenoic Acid / blood
Fatty Acids / blood
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*, deficiency
Italy / epidemiology
Linoleic Acid / blood
Peripheral Nervous System Diseases / blood, physiopathology
Peripheral Vascular Diseases / epidemiology
Peroneal Nerve / physiology*
Predictive Value of Tests
Triglycerides / blood
alpha-Linolenic Acid / blood
|Z99 AG999999/AG/NIA NIH HHS|
|0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol|
|Eur J Neurol. 2007 Sep;14(9):1071
Note: Benedetta, B [corrected to Bartali, B]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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