Document Detail

Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons.
MedLine Citation:
PMID:  17594339     Owner:  NLM     Status:  MEDLINE    
Pre-clinical studies suggest that both omega-6 and omega-3 fatty acids have beneficial effects on peripheral nerve function. Rats feed a diet rich in polyunsaturated fatty acids (PUFAs) showed modification of phospholipid fatty acid composition in nerve membranes and improvement of sciatic nerve conduction velocity (NCV). We tested the hypothesis that baseline plasma omega-6 and omega-3 fatty acids levels predict accelerated decline of peripheral nerve function. Changes between baseline and the 3-year follow-up in peripheral nerve function was assessed by standard surface ENG of the right peroneal nerve in 384 male and 443 female participants of the InCHIANTI study (age range: 24-97 years). Plasma concentrations of selected fatty acids assessed at baseline by gas chromatography. Independent of confounders, plasma omega-6 fatty acids and linoleic acid were significantly correlated with peroneal NCV at enrollment. Lower plasma PUFA, omega-6 fatty acids, linoleic acid, ratio omega-6/omega-3, arachidonic acid and docosahexanoic acid levels were significantly predicted a steeper decline in nerve function parameters over the 3-year follow-up. Low plasma omega-6 and omega-3 fatty acids levels were associated with accelerated decline of peripheral nerve function with aging.
F Lauretani; S Bandinelli; B Bartali; B Benedetta; A Cherubini; A D Iorio; A Blè; V Giacomini; A M Corsi; J M Guralnik; L Ferrucci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  14     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-27     Completed Date:  2007-08-15     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  801-8     Citation Subset:  IM    
Tuscany Regional Health Agency, Florence, Italy.
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Arachidonic Acid / blood
Cholesterol / blood
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus / epidemiology
Docosahexaenoic Acids / blood
Eicosapentaenoic Acid / blood
Fatty Acids / blood
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*,  deficiency
Follow-Up Studies
Italy / epidemiology
Linoleic Acid / blood
Middle Aged
Neural Conduction
Peripheral Nervous System Diseases / blood,  physiopathology
Peripheral Vascular Diseases / epidemiology
Peroneal Nerve / physiology*
Predictive Value of Tests
Triglycerides / blood
alpha-Linolenic Acid / blood
Grant Support
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol
Erratum In:
Eur J Neurol. 2007 Sep;14(9):1071
Note: Benedetta, B [corrected to Bartali, B]

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