Document Detail


Omega-3 polyunsaturated fatty acids promote liver regeneration after 90% hepatectomy in rats.
MedLine Citation:
PMID:  22783054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate the effectiveness of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration on liver regeneration after 90% partial hepatectomy (PH) in rats.
METHODS: ω-3 PUFAs were intravenously injected in the ω-3 PUFA group before PH surgery. PH, sparing only the caudate lobe, was performed in both the control and the ω-3 PUFA group. Survival rates, liver weight/body weight ratios, liver weights, HE staining, transmission electron microscope imaging, nuclear-associated antigen Ki-67, enzyme-linked immunosorbent assay and signal transduction were evaluated to analyze liver regeneration.
RESULTS: All rats in the control group died within 30 h after hepatectomy. Survival rates in the ω-3 PUFA group were 20/20 at 30 h and 4/20 1 wk after PH. Liver weight/body weight ratios and liver weights increased significantly in the ω-3 PUFA group. The structure of sinusoidal endothelial cells and space of Disse was greatly restored in the ω-3 PUFA group compared to the control group after PH. In the ω-3 PUFA group, interleukin (IL)-4 and IL-10 levels were significantly increased whereas IL-6 and tumor necrosis factor-α levels were dramatically decreased. In addition, activation of protein kinase B (Akt) and of signal transducer and activator of transcription 3 signaling pathway were identified at an earlier time after PH in the ω-3 PUFA group.
CONCLUSION: Omega-3 polyunsaturated fatty acids may prevent acute liver failure and promote liver regeneration after 90% hepatectomy in rats.
Authors:
Yu-Dong Qiu; Sheng Wang; Yue Yang; Xiao-Peng Yan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-11     Completed Date:  2012-11-21     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3288-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood
Cytokines / blood
Enzyme-Linked Immunosorbent Assay
Fatty Acids, Omega-3 / administration & dosage,  pharmacology*
Glycogen Synthase Kinase 3 / metabolism
Hepatectomy* / adverse effects
Inflammation Mediators / blood
Injections, Intravenous
Liver / drug effects*,  metabolism,  surgery*,  ultrastructure
Liver Failure, Acute / etiology,  pathology,  prevention & control
Liver Regeneration / drug effects*
Male
Microscopy, Electron, Transmission
Organ Size
Phosphorylation
Proto-Oncogene Proteins c-akt / metabolism
Rats
Rats, Sprague-Dawley
STAT3 Transcription Factor / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Fatty Acids, Omega-3; 0/Inflammation Mediators; 0/STAT3 Transcription Factor; 0/Stat3 protein, rat; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/glycogen synthase kinase 3 beta; EC 2.7.11.26/Glycogen Synthase Kinase 3
Comments/Corrections

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