| Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection. | |
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MedLine Citation:
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PMID: 21622201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are a group of essential fatty acids that serve as energy substrates and integral membrane components, and therefore play crucial roles in the maintenance of normal neurological function. Recent studies show that n-3 PUFAs display neuroprotective properties and exert beneficial effects on the cognitive function with aging. The brain's need of n-3 PUFAs is predominantly met by the blood delivery due to their limited synthesis in the brain. The present review focuses on the metabolism of n-3 PUFAs in the brain, including their accumulation and turnover. We also highlight the current understanding of the neuroprotective effects of n-3 PUFAs against cerebral ischemia and neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. |
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Authors:
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Wenting Zhang; Peiying Li; Xiaoming Hu; Feng Zhang; Jun Chen; Yanqin Gao |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-06-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 16 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-30 Completed Date: 2011-10-03 Revised Date: 2012-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 2653-70 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Medical Neurobiology, Anesthesiology Department of Huanshan Hospital, Fudan University, Shanghai 200032, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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diet therapy,
etiology,
metabolism Animals Biological Transport, Active Brain / drug effects, metabolism* Brain Ischemia / diet therapy, etiology, metabolism Fatty Acids, Omega-3 / metabolism*, pharmacology Humans Models, Neurological Neuroprotective Agents / metabolism*, pharmacology Parkinson Disease / diet therapy, etiology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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NS036736/NS/NINDS NIH HHS; NS056118/NS/NINDS NIH HHS; NS062157/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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