Document Detail

Omega 3 polyunsaturated fatty acids supplementation and blood pressure levels in hypertriglyceridemic patients with untreated normal-high blood pressure and with or without metabolic syndrome: a retrospective study.
MedLine Citation:
PMID:  20374188     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that at least a part of the polyunsaturated fatty acids (PUFAs) heart protective effect is mediated by a relatively small but significant decrease in blood pressure level. We retrospectively evaluated the long-term effect of a PUFA supplementation on the blood pressure level of 111 hypertriglyceridemic subjects with untreated normal-high blood pressure that were prescribed a 2 grams PUFA supplementation in order to improve their plasma lipid pattern. After 12 months of treatment, systolic blood pressure (SBP) meanly decreased by 2.7 +/- 2.5 mmHg (p = 0.001) and diastolic blood pressure (DBP) by 1.3 +/- 3.3 mmHg (p < 0.001), while basal heart rate decreased by 4.0 +/- 4.4 bpm (p < 0.001). Both SBP and DBP reduction were significantly related to the baseline SBP (p < 0.001) and DBP (p < 0.001), respectively. Diastolic blood pressure change was also inversely related to the patient's age (p = 0.004). No significant difference was perceived in the metabolic syndrome subgroup. In our retrospective study, highly purified omega-3 PUFA long-term supplementation is associated with a significant reduction in SBP, DBP, Pulse pressure (PP), and basal heart rate in hypertriglyceridemic patients with normal-high blood pressure. No significant difference was perceived in the metabolic syndrome subgroup. The main determinants of the PUFA anti-hypertensive effect appear to be the basal blood pressure level and age.
Arrigo F G Cicero; Giuseppe Derosa; Valentina Di Gregori; Marilisa Bove; Antonio V Gaddi; Claudio Borghi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  32     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
Lipid Research Unit, Department of Internal Medicine, Aging and Kidney Diseases, Alma Mater Studiorum University of Bologna, Bologna, Italy.
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MeSH Terms
Aged, 80 and over
Blood Pressure*
Cardiovascular Diseases / prevention & control
Dietary Supplements
Fatty Acids, Omega-3 / administration & dosage*
Hypertension / physiopathology,  prevention & control*
Hypertriglyceridemia / complications,  diet therapy*,  physiopathology*
Lipids / blood
Metabolic Syndrome X / complications,  diet therapy*,  physiopathology*
Middle Aged
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Lipids

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