Document Detail

Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study.
MedLine Citation:
PMID:  22915050     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Animal and laboratory studies suggest that long-chain omega-3 (n-3) fatty acids, a type of polyunsaturated fat found in fatty fish, may protect against carcinogenesis, but human studies on dietary intake of polyunsaturated fats and fish with endometrial cancer risk show mixed results.
METHODS: We evaluated the associations between endometrial cancer risk and intake of fatty acids and fish in a population-based sample of 556 incident cancer cases and 533 age-matched controls using multivariate unconditional logistic regression methods.
RESULTS: Although total n-3 fatty acid intake was not associated with endometrial cancer risk, higher intakes of eicosapentaenoic (EPA 20:5) and docosahexaenoic (DHA 22:6) fatty acids were significantly associated with lower risks (OR = 0.57, 95 % CI: 0.39-0.84; OR = 0.64, 95 % CI: 0.44-0.94; respectively) comparing extreme quartiles. The ratio of n-3:n-6 fatty acids was inversely associated with risk only on a continuous scale (OR = 0.84, 95 % CI: 0.71-0.99), while total fish intake was not associated with risk. Fish oil supplement use was significantly associated with reduced risk of endometrial cancer: OR = 0.63 (95 % CI: 0.45-0.88).
CONCLUSIONS: Our results suggest that dietary intake of the long-chain polyunsaturated fatty acids EPA and DHA in foods and supplements may have protective associations against the development of endometrial cancer.
Hannah Arem; Marian L Neuhouser; Melinda L Irwin; Brenda Cartmel; Lingeng Lu; Harvey Risch; Susan T Mayne; Herbert Yu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-23
Journal Detail:
Title:  European journal of nutrition     Volume:  52     ISSN:  1436-6215     ISO Abbreviation:  Eur J Nutr     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-29     Completed Date:  2013-10-21     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1251-60     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Connecticut / epidemiology
Diet* / adverse effects
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage,  therapeutic use*
Eicosapentaenoic Acid / administration & dosage,  therapeutic use*
Endometrial Neoplasms / epidemiology,  etiology,  prevention & control*
Fatty Acids, Omega-3 / administration & dosage
Fatty Acids, Omega-6 / administration & dosage
Fish Oils / administration & dosage,  therapeutic use*
Middle Aged
Reproducibility of Results
Grant Support
5R01 CA098346/CA/NCI NIH HHS; P30 CA15704/CA/NCI NIH HHS; R01 CA098346/CA/NCI NIH HHS; T32 CA105666/CA/NCI NIH HHS; T32 CA105666/CA/NCI NIH HHS
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fish Oils; 25167-62-8/Docosahexaenoic Acids; AAN7QOV9EA/Eicosapentaenoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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