Document Detail


Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study.
MedLine Citation:
PMID:  19154523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Bronchial asthma is a chronic inflammatory airways disease. Nutritional intervention is an important tool to decrease the severity of many chronic inflammatory diseases including asthma. The aim of this study is to evaluate the role of omega-3 fatty acids, vitamin C and Zn in children with moderately persistent asthma.
PATIENTS AND METHODS: Randomly assigned, placebo-self-controlled 60 children with moderate persistent asthma completed the study, were subjected to alternating phases of supplementation with omega-3 fatty acids, vitamin C and Zn either singly or in combination separated with washout phases. Childhood asthma control test (C-ACT), pulmonary function tests and sputum inflammatory markers were evaluated at the beginning of the study and at the end of each therapeutic phase.
RESULTS: There was a significant improvement of C-ACT, pulmonary function tests and sputum inflammatory markers with diet supplementation with omega-3 fatty acids, vitamin C and Zn (p < 0.001*). There was also significant improvement with the combined use of the three supplementations than single use of any one of them (p < 0.001*).
CONCLUSION: Diet supplementation with omega-3 fatty acids, Zn and vitamin C significantly improved asthma control test, pulmonary function tests and pulmonary inflammatory markers in children with moderately persistent bronchial asthma either singly or in combination.
Authors:
Mohammed Al Biltagi; Ahmed Abdul Baset; Mohammed Bassiouny; Mohammed Al Kasrawi; Mohammed Attia
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Retracted Publication     Date:  2008-01-11
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-07-13     Revised Date:  2012-09-13    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  737-42     Citation Subset:  IM    
Affiliation:
Department of Paediatric, Faculty of Medicine, Tanta University, Tanta, Egypt. mbelrem@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Ascorbic Acid / administration & dosage*
Asthma / drug therapy*
Biological Markers / metabolism
Child
Cross-Over Studies
Dietary Supplements
Fatty Acids, Omega-3 / administration & dosage*
Female
Humans
Inflammation Mediators / metabolism
Male
Respiration / drug effects
Respiratory Function Tests
Sputum / metabolism
Zinc / administration & dosage*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Inflammation Mediators; 50-81-7/Ascorbic Acid; 7440-66-6/Zinc
Comments/Corrections
Retraction In:
Acta Paediatr. 2012 Aug;101(8):891   [PMID:  22970440 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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