| Omega-3 fatty acids suppress Th2-associated cytokine gene expressions and GATA transcription factors in mast cells. | |
| | |
MedLine Citation:
|
PMID: 22902330 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Because the interaction between omega-3 fatty acids and mast cells has remained largely unknown in allergies, we investigated whether omega-3 fatty acids affect the activation of mast cells by examining Th2-associated cytokine production and possible molecular mechanisms. Alpha-linolenic acid and its metabolites including eicosapentaenoic acid and decosahexaenoic acid induced a dramatic decrease in the production of interleukin (IL)-4, IL-5 and IL-13 in a dose-dependent manner, as well as mRNA expression of their genes, in activated MC/9 mast cells and bone marrow-derived mast cells. The effects were comparable to those of cyclosporin A (1 μM), a well-known immunosuppressive agent. Nuclear expression of GATA binding protein-1 (GATA-1) and GATA binding protein-2 (GATA-2), essential transcription factors for mast cell activation, was also greatly suppressed. However, their mRNA expressions were not affected. In P815 mast cells, which do not express GATA-1, the suppressive effects on cytokines were abolished. On the contrary, omega-3 fatty acids had less significant effects on IL-4 and IL-5 and resulted in a slight decrease in IL-13 production in EL-4 T cells. Finally, oral administration of fish oil containing high level of omega-3 fatty acids significantly reduced the severity of dermatitis and the thickening of epidermis/dermis in a NC/Nga murine atopic model. The number of cells expressing CD117(+) and FcεRIα(+) was greatly decreased and GATA-1 expression in the cells was also diminished. Taken together, omega-3 fatty acids might target mast cells to a greater extent than T cells to suppress Th2 cytokine expression by inhibiting GATAs for alleviation of allergic disease. |
| | |
Authors:
|
Bo-Kyung Park; Sunyoung Park; Jun-Beom Park; Min Chul Park; Tae Sun Min; Mirim Jin |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-16 |
Journal Detail:
|
Title: The Journal of nutritional biochemistry Volume: - ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Lab of Pathology, College of Oriental Medicine, Daejeon University, Daejeon, 300-716, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin E deficiency impairs the somatostatinergic receptor-effector system and leads to phosphotyro...
Next Document: Zinc deficiency induces production of the proinflammatory cytokines IL-1? and TNF? in promyeloid cel...