Document Detail


Omega-3 fatty acids and neuropsychiatric disorders.
MedLine Citation:
PMID:  15865053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological evidence suggests that dietary consumption of the long chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), commonly found in fish or fish oil, may modify the risk for certain neuropsychiatric disorders. As evidence, decreased blood levels of omega-3 fatty acids have been associated with several neuropsychiatric conditions, including Attention Deficit (Hyperactivity) Disorder, Alzheimer's Disease, Schizophrenia and Depression. Supplementation studies, using individual or combination omega-3 fatty acids, suggest the possibility for decreased symptoms associated with some of these conditions. Thus far, however, the benefits of supplementation, in terms of decreasing disease risk and/or aiding in symptom management, are not clear and more research is needed. The reasons for blood fatty acid alterations in these disorders are not known, nor are the potential mechanisms by which omega-3 fatty acids may function in normal neuronal activity and neuropsychiatric disease prevention and/or treatment. It is clear, however, that DHA is the predominant n-3 fatty acid found in the brain and that EPA plays an important role as an anti-inflammatory precursor. Both DHA and EPA can be linked with many aspects of neural function, including neurotransmission, membrane fluidity, ion channel and enzyme regulation and gene expression. This review summarizes the knowledge in terms of dietary omega-3 fatty acid intake and metabolism, as well as evidence pointing to potential mechanisms of omega-3 fatty acids in normal brain functioning, development of neuropsychiatric disorders and efficacy of omega-3 fatty acid supplementation in terms of symptom management.
Authors:
Genevieve Young; Julie Conquer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reproduction, nutrition, development     Volume:  45     ISSN:  0926-5287     ISO Abbreviation:  Reprod. Nutr. Dev.     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-05-03     Completed Date:  2005-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913069     Medline TA:  Reprod Nutr Dev     Country:  France    
Other Details:
Languages:  eng     Pagination:  1-28     Citation Subset:  IM    
Affiliation:
Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / metabolism,  prevention & control
Attention Deficit Disorder with Hyperactivity / metabolism,  prevention & control
Autistic Disorder / metabolism,  prevention & control
Brain / metabolism*
Depressive Disorder / metabolism,  prevention & control
Fatty Acids, Omega-3 / administration & dosage*,  blood,  physiology*
Humans
Mental Disorders / metabolism,  prevention & control*
Schizophrenia / metabolism,  prevention & control
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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