| Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action. | |
| | |
MedLine Citation:
|
PMID: 21762726 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Epidemiological, human, animal, and cell culture studies show that n-3 fatty acids, especially α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), reduce the risk factors of cardiovascular diseases. EPA and DHA, rather than ALA, have been the focus of research on the n-3 fatty acids, probably due to the relatively inefficient conversion of ALA to EPA and DHA in rodents and humans. This review will assess our current understanding of the effects and potential mechanisms of actions of individual n-3 fatty acids on multiple risk factors of metabolic syndrome. Evidence for pharmacological responses and the mechanism of action of each of the n-3 fatty acid trio will be discussed for the major risk factors of metabolic syndrome, especially adiposity, dyslipidemia, insulin resistance and diabetes, hypertension, oxidative stress and inflammation. Metabolism of n-3 and n-6 fatty acids as well as the interactions of n-3 fatty acids with nutrients, gene expression and disease states will be addressed to provide a rationale for the use of n-3 fatty acids to reduce the risk factors of metabolic syndrome. |
| | |
Authors:
|
Hemant Poudyal; Sunil K Panchal; Vishal Diwan; Lindsay Brown |
Related Documents
:
|
18959846 - Determination of boron in nickel-base alloys by the dianthrimide method. 6867606 - Why concentration of serum ferritin does not in all circumstances reflect storage iron ... 11225696 - Comparative study on sorption/desorption of radioeuropium on alumina, bentonite and red... 12195996 - Evolution of water chemistry in natural acidic environments in yangmingshan, taiwan. 3989816 - Studies on antianaphylactic agents. 7. synthesis of antiallergic 5-oxo-5h-[1]benzopyran... 717286 - A modified sensitive spectrofluorometric method for the determination of propranolol in... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-3 |
Journal Detail:
|
Title: Progress in lipid research Volume: - ISSN: 1873-2194 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7900832 Medline TA: Prog Lipid Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
School of Biomedical Sciences, The University of Queensland, Qld 4072, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prospective study on neurotoxic effects in manganese-exposed bridge construction welders.
Next Document: Development of ELISA to measure TRPV1 protein in rat tissues.