| Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. | |
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MedLine Citation:
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PMID: 21037490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to obtain preliminary data regarding the efficacy of omega-3 fatty acids for major depressive disorder associated with the menopausal transition. Secondary outcomes were assessed for vasomotor symptoms (or hot flashes). METHODS: After a single-blind placebo lead-in, participants received 8 weeks of treatment with open-label omega-3 fatty acid capsules (eicosapentaenoic acid and docosahexaenoic acid, 2 g/d). The Montgomery-Asberg Depression Rating Scale (MADRS) was the primary outcome measure. Hot flashes were monitored prospectively using daily diaries and the Hot Flash Related Daily Interference Scale. Blood samples for plasma pretreatment and posttreatment essential fatty acid assays were obtained. Because of the small sample size, data were analyzed using nonparametric techniques. RESULTS: Of 20 participants treated with omega-3 fatty acids, 19 (95%) completed the study. None discontinued because of adverse effects. The pretreatment and final mean MADRS scores were 24.2 and 10.7, respectively, reflecting a significant decrease in MADRS scores (P < 0.0001). The response rate was 70% (MADRS score decrease of ≥50%), and the remission rate was 45% (final MADRS score of ≤). Responders had significantly lower pretreatment docosahexaenoic acid levels than nonresponders did (P = 0.03). Hot flashes were present in 15 (75%) participants. Among those with hot flashes at baseline, the number of hot flashes per day improved significantly from baseline (P = 0.02) and Hot Flash Related Daily Interference Scale scores decreased significantly (P = 0.006). CONCLUSIONS: These data support further study of omega-3 fatty acids for major depressive disorder and hot flashes in women during the menopausal transition. |
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Authors:
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Marlene P Freeman; Joseph R Hibbeln; Michael Silver; April M Hirschberg; Betty Wang; Amy M Yule; Laura F Petrillo; Erica Pascuillo; Nicole I Economou; Hadine Joffe; Lee S Cohen |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 18 ISSN: 1530-0374 ISO Abbreviation: Menopause Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: 2011-06-09 Revised Date: 2011-10-17 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 279-84 Citation Subset: IM |
Affiliation:
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Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. mfreeman@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Depressive Disorder, Major
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blood,
drug therapy* Docosahexaenoic Acids / blood Fatty Acids, Omega-3 / adverse effects, therapeutic use* Female Hot Flashes / drug therapy Humans Menopause / psychology* Middle Aged Placebos Psychiatric Status Rating Scales Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Placebos; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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