| Omega-3 fatty acids increase the arachidonic acid content of liver cholesterol ester and plasma triacylglycerol fractions in the rat. | |
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MedLine Citation:
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PMID: 2775198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have demonstrated that dietary fish oils rich in eicosapentaenoic acid (C20:5,omega 3) lower the content of arachidonic acid and its metabolites in plasma and tissue phospholipids. The present study examined the fatty acid composition of cholesterol ester and triacylglycerol fractions from plasma and livers of rats fed diets enriched with saturated fatty acids (beef tallow), alpha-linolenic acid (linseed oil) or eicosapentaenoic acid (fish oil). Feeding diets containing linseed oil or fish oil for 28 days increased arachidonic acid (C20:4,omega 6) levels in the cholesterol ester fraction of liver and in the triacylglycerol fraction of the plasma lipids. Plasma cholesterol esters were depleted of C20:4,omega 6 after feeding of the diet containing either linseed oil or fish oil. The changes in C20:4,omega 6 content cannot be explained by alterations in cholesterol ester or triacylglycerol pools of plasma and liver. These results suggest that the decrease in phospholipid C20:4,omega 6 content generally observed after fish oil consumption may be partly due to a shift of C20:4,omega 6 from phospholipid to the triacylglycerol and/or cholesterol ester pools in the same tissue. Triacylglycerols and cholesterol esters may therefore play a buffering role in the homeostatic maintenance of tissue phospholipid levels of arachidonic acid. |
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Authors:
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M L Garg; A A Wierzbicki; A B Thomson; M T Clandinin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Biochemical journal Volume: 261 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-09-27 Completed Date: 1989-09-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 11-5 Citation Subset: IM |
Affiliation:
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Department of Foods and Nutrition, Faculty of Home Economics, University of Alberta, Edmonton, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acids / metabolism* Cholesterol Esters / metabolism* Dietary Fats, Unsaturated / administration & dosage Fatty Acids, Unsaturated / administration & dosage* Fish Oils / administration & dosage Linseed Oil / administration & dosage Liver / metabolism* Male Rats Rats, Inbred Strains Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Cholesterol Esters; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Triglycerides; 8001-26-1/Linseed Oil |
| Comments/Corrections | |
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