| Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. | |
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MedLine Citation:
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PMID: 15353491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel function. The extent of incorporation has not been determined in humans. METHODS AND RESULTS: We first determined the correlation between red blood cell (RBC) and cardiac omega-3 FA levels in 20 heart transplant recipients. We then examined the effects of 6 months of omega-3 FA supplementation (1 g/d) on the FA composition of human cardiac and buccal tissue, RBCs, and plasma lipids in 25 other patients. Cardiac and RBC EPA+DHA levels were highly correlated (r=0.82, P<0.001). Supplementation increased EPA+DHA levels in cardiac tissue by 110%, in RBCs by 101%, in plasma by 139%, and in cheek cells by 73% (P<0.005 versus baseline for all; responses among tissues were not significantly different). CONCLUSIONS: Although any of the tissues examined could serve as a surrogate for cardiac omega-3 FA content, RBC EPA+DHA was highly correlated with cardiac EPA+DHA; the RBC omega-3 response to supplementation was similar to that of the heart; RBCs are easily collected and analyzed; and they have a less variable FA composition than plasma. Therefore, RBC EPA+DHA (also called the Omega-3 Index) may be the preferred surrogate for cardiac omega-3 FA status. |
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Authors:
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William S Harris; Scott A Sands; Sheryl L Windsor; Hakim A Ali; Tracy L Stevens; Anthony Magalski; Charles B Porter; A Michael Borkon |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2004-09-07 |
Journal Detail:
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Title: Circulation Volume: 110 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-21 Completed Date: 2005-06-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 1645-9 Citation Subset: AIM; IM |
Affiliation:
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Mid America Heart Institute, Saint Luke's Hospital, Kansas City, Mo, USA. wharris@saint-lukes.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Cheek Cross-Sectional Studies Dietary Fats, Unsaturated / pharmacology Dietary Supplements Docosahexaenoic Acids / analysis Erythrocytes / chemistry* Fatty Acids, Omega-3 / administration & dosage, analysis*, blood, pharmacology Female Fish Oils / administration & dosage, pharmacology Fishes Heart / drug effects Heart Catheterization Heart Transplantation* Humans Lipids / blood Lipoproteins / blood Male Meat Middle Aged Mouth Mucosa / chemistry, drug effects Myocardium / chemistry*, pathology Organ Specificity |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Lipids; 0/Lipoproteins; 25167-62-8/Docosahexaenoic Acids |
| Comments/Corrections | |
Erratum In:
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Circulation. 2004 Nov 9;110(19):3156 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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