Document Detail

Omega-3 fatty acids: how can they be used in secondary prevention?
MedLine Citation:
PMID:  18937899     Owner:  NLM     Status:  MEDLINE    
Omega-3 fatty acids (FAs) are divided into long-chain fatty acids (eicosapentaenoic acid and docosahexaenoic acid ), which are found in fatty fish, and intermediate-chain FAs (alpha-linolenic acid), which are found in vegetable oils. Omega-3 FAs favorably modulate a variety of vascular risk factors and also exert antiarrhythmic effects. Epidemiologic data suggest that increased consumption of marine omega-3 FAs is associated with reduced coronary heart disease (CHD) mortality. Randomized controlled studies also show that supplementation with EPA and DHA reduces CHD risk, primarily in the secondary prevention setting. Data are more limited on the efficacy of marine omega-3 FAs for the primary prevention of CHD and on the role of alpha-linolenic acid. Increased intake of EPA and DHA represents a valuable tool for vascular disease prevention and should be recommended in all patients with CHD.
Konstantinos Tziomalos; Vasilios G Athyros; Asterios Karagiannis; Dimitri P Mikhailidis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  10     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2009-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-7     Citation Subset:  IM    
Second Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, 63 Solonos Street, Thessaloniki, 54248, Greece.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Coronary Disease / prevention & control*
Fatty Acids, Omega-3 / therapeutic use*
Meta-Analysis as Topic
Secondary Prevention
Vascular Diseases / prevention & control
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Fatty Acids, Omega-3

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