Document Detail


Omega-3 fatty acids, genetic variants in COX-2 and prostate cancer.
MedLine Citation:
PMID:  19776642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary intake of fish and omega-3 polyunsaturated fatty acids (omega-3 PUFAs) may decrease the risk of prostate cancer development and progression to advanced stage disease. This could reflect the anti-inflammatory effects of PUFAs, possibly through mediation of cyclooxygenase (COX), a key enzyme in fatty acid metabolism and inflammation. Despite promising experimental evidence, epidemiological studies have reported somewhat conflicting results regarding the effects of fish/PUFAs on prostate cancer development and progression. The literature suggests that fish, and particularly long-chain omega-3 PUFAs, may have a more pronounced protective effect on biologically aggressive tumors or on their progression, and less on early steps of carcinogenesis. Moreover, the impact of LC omega-3 PUFAs may be modified by variation of the COX-2 gene. Overall, results to date support the hypothesis that long-chain omega-3 PUFAs may impact prostate inflammation and carcinogenesis via the COX-2 enzymatic pathway.
Authors:
Adam C Reese; Vincent Fradet; John S Witte
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-09-23
Journal Detail:
Title:  Journal of nutrigenetics and nutrigenomics     Volume:  2     ISSN:  1661-6499     ISO Abbreviation:  J Nutrigenet Nutrigenomics     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-15     Completed Date:  2010-01-06     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101299758     Medline TA:  J Nutrigenet Nutrigenomics     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  149-58     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 S. Karger AG, Basel.
Affiliation:
Department of Urology, University of California-San Francisco, CA 94158, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cohort Studies
Cyclooxygenase 2 / genetics*,  metabolism
Diet
Fatty Acids, Omega-3 / therapeutic use*
Fishes
Genetic Variation*
Humans
Inflammation / complications,  genetics
Male
Prostatic Neoplasms / enzymology,  epidemiology,  genetics*,  prevention & control
Risk Factors
Grant Support
ID/Acronym/Agency:
CA 88164/CA/NCI NIH HHS; CA 94211/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; EC 1.14.99.1/Cyclooxygenase 2
Comments/Corrections

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