| Omega-3 fatty acids: essential fatty acids with important biological effects, and serum phospholipid fatty acids as markers of dietary omega 3-fatty acid intake. | |
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MedLine Citation:
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PMID: 8475898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum phospholipid eicosapentaenoic (PL-EPA) and docosahexaenoic acid (PL-DHA) concentrations are associated with the dietary intake of omega 3 fatty acids. PL-EPA and PL-DHA concentrations measured 4 y apart in 211 diabetic patients were highly correlated, with Spearman correlation coefficients of 0.49 (p = 0.0001) and 0.64 (p = 0.0001), respectively. PL-DHA was positively associated with Bayley psychomotor and mental developmental indexes (PDI and MDI, respectively) in preterm infants. Using multiple-regression analysis, 64% (R2 = 0.639; p = 0.0001) of PDI variance was explained by 1/DHA and weight at 1 y, whereas 82% (R2 = 0.816; p = 0.0001) of MDI variance was explained by weight at 1 y, Apgar score, 1/DHA, and 1/EPA. 1/DHA was negatively correlated with PDI and MDI, whereas 1/EPA was positively correlated with MDI. The results suggest that infant formulas should contain preformed DHA, and that a too-high supply of EPA in addition to DHA might be harmful in preterm infants. |
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Authors:
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K S Bjerve; A M Brubakk; K J Fougner; H Johnsen; K Midthjell; T Vik |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 57 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-05-14 Completed Date: 1993-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 801S-805S; discussion 805S-806 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Chemistry, University Hospital of Trondheim, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Development* Child, Preschool Diabetes Mellitus / blood Docosahexaenoic Acids / blood* Eicosapentaenoic Acid / blood* Fatty Acids, Omega-3 / administration & dosage*, blood Humans Infant, Low Birth Weight / blood* Infant, Newborn Phospholipids / blood Psychomotor Performance* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Phospholipids; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids |
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