Document Detail

Omega-3 fatty acids: benefits for cardio-cerebro-vascular diseases.
MedLine Citation:
PMID:  23031363     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Intracranial artery stenosis (ICAS) is a narrowing of an intracranial artery, which is a common etiology for ischemic stroke. In this commentary, we review key aspects of the discrimination between non-stroke controls and ischemic stroke patients on the background of phospholipid ω3-fatty acid (DHA, EPA) composition. The discussion is embedded in the presentation of general effects of long-chain ω3 polyunsaturated fatty acids (PUFAs) in cardio-cerebro-vascular diseases (CCVDs) and Alzheimer dementia (AD).
SUMMARY OF COMMENTARY: ICAS is a common stroke subtype and has emerged as a major factor in recurrent stroke and vascular mortality. DHA and EPA are important fatty acids to distinguish between NCAS (no cerebral arteriosclerotic stenosis) and ICAS in stroke. The risk of ICAS is inversely correlated with the DHA content in phospholipids. Furthermore, a mechanistic explanation has been proposed for the beneficial effects of PUFAs in CCVDs and AD.
CONCLUSIONS: Whereas the beneficial effects of EPA/DHA for cardiovascular diseases and stroke seem to be beyond question, preventive effects in patients with very mild cognitive dysfunction and beginning Alzheimer's disease undoubtedly need confirmation by larger clinical trials. A collaborative international basic science approach is warranted considering cautiously designed studies in order to avoid ethical problems.
G Siegel; E Ermilov
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-09-18
Journal Detail:
Title:  Atherosclerosis     Volume:  225     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-02     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Charité - University Clinic Berlin, D-14195 Berlin, Germany.
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MeSH Terms
Alzheimer Disease / prevention & control
Cardiovascular Agents / administration & dosage*
Cardiovascular Diseases / prevention & control*
Cerebrovascular Disorders / prevention & control*
Constriction, Pathologic
Dementia, Vascular / prevention & control
Dietary Supplements*
Fatty Acids, Omega-3 / administration & dosage*
Intracranial Arterial Diseases / prevention & control
Nutrition Policy
Stroke / prevention & control
Reg. No./Substance:
0/Cardiovascular Agents; 0/Fatty Acids, Omega-3

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