| Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. | |
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MedLine Citation:
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PMID: 19593941 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Fish-oil contains high concentrations of omega-3 fatty acids that have been shown to have anti-inflammatory properties. We have evaluated the effects of purified omega-3 fatty acid supplements on several anthropometric and biochemical parameters, including heat shock protein (Hsp) 27 antibody titres in subjects with metabolic syndrome. METHODS: Subjects (n = 120) with metabolic syndrome (mean age of 52.9 +/- 11.9 years) were randomly allocated to one of two groups: sixty subjects were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period. RESULTS: The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group. CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity. |
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Authors:
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Mahmoud Ebrahimi; Majid Ghayour-Mobarhan; Samaneh Rezaiean; Maryam Hoseini; Seyyed Mohamad Reza Parizade; Fatemeh Farhoudi; Syyed Javad Hosseininezhad; Shima Tavallaei; Amirhosein Vejdani; Mohsen Azimi-Nezhad; Mohamad Taghi Shakeri; Mina Akbari Rad; Naser Mobarra; Seyyed Mohammad Reza Kazemi-Bajestani; Gordon A A Ferns |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta cardiologica Volume: 64 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 321-7 Citation Subset: IM |
Affiliation:
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Heart and Vascular Research Centre, Avicenna (Bu-Ali) Research Institute, MUMS, Mashhad, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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