| Omega-3 fatty acid supplementation and cardiovascular disease. | |
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MedLine Citation:
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PMID: 22904344 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C20-22 omega-3 polyunsaturated fatty acids (PUFA)], blood levels of C20-22 omega-3 PUFA and mortality associated with cardiovascular disease [CVD]. C20-22 omega-3 PUFA have pleiotropic effects on cell function and regulate multiple pathways controlling blood lipids, inflammatory factors and cellular events in cardiomyocytes and vascular endothelial cells. The hypolipemic, anti-inflammatory, anti-arrhythmic properties of these fatty acids confer cardioprotection. Accordingly, national heart associations and government agencies have recommended increased consumption of fatty fish or omega-3 PUFA supplements to prevent CVD. In addition to fatty fish, additional sources of omega-3 PUFA are available from plants, algae and yeast. A key question examined in this review is whether non-fish sources of omega-3 PUFA are as effective as fatty fish-derived C20-22 omega-3 PUFA at managing risk factors linked to CVD. We have focused on omega-3 PUFA metabolism and the capacity of omega-3 PUFA supplements to regulate key cellular events linked to CVD. The outcome of our analysis reveals that non-fish sources of omega-3 PUFA vary in their capacity to regulate blood levels of C20-22 omega-3 PUFA and CVD risk factors. |
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Authors:
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Donald B Jump; Christopher M Depner; Sasmita Tripathy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-17 |
Journal Detail:
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Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Oregon State University, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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