Document Detail


Omega-3 fatty acid supplementation enhances stroke volume and cardiac output during dynamic exercise.
MedLine Citation:
PMID:  18563435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects on cardiovascular function. We tested the hypotheses that dietary supplementation with DHA (2 g/day) + EPA (3 g/day) enhances increases in stroke volume (SV) and cardiac output (CO) and decreases in systemic vascular resistance (SVR) during dynamic exercise. Healthy subjects received DHA + EPA (eight men, four women) or safflower oil (six men, three women) for 6 weeks. Both groups performed 20 min of bicycle exercise (10 min each at a low and moderate work intensity) before and after DHA + EPA or safflower oil treatment. Mean arterial pressure (MAP), heart rate (HR), SV, CO, and SVR were assessed before exercise and during both workloads. HR was unaffected by DHA + EPA and MAP was reduced, but only at rest (88 +/- 5 vs. 83 +/- 4 mm Hg). DHA + EPA augmented increases in SV (14.1 +/- 6.3 vs. 32.3 +/- 8.7 ml) and CO (8.5 +/- 1.0 vs. 10.3 +/- 1.2 L/min) and tended to attenuate decreases in SVR (-7.0 +/- 0.6 vs. -10.1 +/- 1.6 mm Hg L(-1) min(-1)) during the moderate workload. Safflower oil treatment had no effects on MAP, HR, SV, CO or SVR at rest or during exercise. DHA + EPA-induced increases in SV and CO imply that dietary supplementation with these fatty acids can increase oxygen delivery during exercise, which may have beneficial clinical implications for individuals with cardiovascular disease and reduced exercise tolerance.
Authors:
Buddy Walser; Charles L Stebbins
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2008-06-18
Journal Detail:
Title:  European journal of applied physiology     Volume:  104     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, One Shields Ave. TB-172, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling
Blood Pressure / drug effects
Cardiac Output / drug effects*
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage*
Eicosapentaenoic Acid / administration & dosage*
Exercise / physiology*
Exercise Tolerance / drug effects
Female
Heart Rate / drug effects
Humans
Male
Middle Aged
Safflower Oil / administration & dosage*
Stroke Volume / drug effects*
Treatment Outcome
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
P30-DK35747/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 8001-23-8/Safflower Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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