Document Detail

Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers.
MedLine Citation:
PMID:  22000931     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the use of fish oil in the dietary management of hypercalciuric stone formers. Prostaglandins have been linked to urinary calcium excretion, suggesting a role for omega-3 fatty acids in the treatment of hypercalciuric urolithiasis.
METHODS: We retrospectively studied a cohort of patients treated at our stone clinics from July 2007 to February 2009. Patients' urinary risk factors for stone disease were evaluated with pre- and post-intervention 24-hour urine collections. All patients received empiric dietary recommendations for intake of fluids, sodium, protein, and citric juices. All subjects with hypercalciuria (urinary calcium>250 mg/d for males or >200 mg/d for females) on at least two 24-hour urine collections were counseled to supplement their diet with fish oil (1200 mg/d).
RESULTS: Twenty-nine patients were followed for 9.86±8.96 months. The mean age was 43.38±13.78 years. Urinary calcium levels decreased in 52% of patients, with 24% converting to normocalciuria. The average urinary calcium (mg/d) decreased significantly from baseline (329.27±96.23 to 247.47±84.53, P<.0001). Urinary oxalate excretion decreased in 34% of patients. The average urinary oxalate (mg/d) decreased significantly from baseline (45.40±9.90 to 32.9±8.21, P=.0004). Urinary citrate (mg/d) increased in 62% of subjects from baseline (731.67±279.09 to 940.22±437.54, P=.0005). Calcium oxalate supersaturation decreased in 38% of the subjects significantly from baseline (9.73±4.48 to 3.68±1.76, P=.001).
CONCLUSION: Omega-3 fatty acids combined with empiric dietary counseling results in a measurable decrease in urinary calcium and oxalate excretion and an increase in urinary citrate in hypercalciuric stone formers.
Omar Ortiz-Alvarado; Ricardo Miyaoka; Carly Kriedberg; David A Leavitt; Angela Moeding; Michelle Stessman; Manoj Monga
Publication Detail:
Type:  Journal Article     Date:  2011-10-13
Journal Detail:
Title:  Urology     Volume:  79     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-07     Completed Date:  2012-05-17     Revised Date:  2012-08-02    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Regional Urology, The Cleveland Clinic, Cleveland, OH 44195, USA.
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MeSH Terms
Calcium / urine
Citrates / urine
Combined Modality Therapy
Cyclooxygenase Inhibitors / therapeutic use*
Dietary Supplements*
Docosahexaenoic Acids / therapeutic use*
Drug Evaluation
Eicosapentaenoic Acid / therapeutic use*
Fish Oils / therapeutic use*
Follow-Up Studies
Hypercalciuria / complications,  diet therapy,  drug therapy*,  urine
Middle Aged
Oxalates / urine
Prostaglandins / metabolism
Retrospective Studies
Urolithiasis / diet therapy,  etiology,  prevention & control*,  urine
Reg. No./Substance:
0/Citrates; 0/Cyclooxygenase Inhibitors; 0/Fish Oils; 0/Oxalates; 0/Prostaglandins; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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