| Omega-3 fatty acids, cognitive decline, and Alzheimer's disease: a critical review and evaluation of the literature. | |
| | |
MedLine Citation:
|
PMID: 20634589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The precipitous decline of memory and independence associated with cognitive decline, dementia, and Alzheimer's disease is emotionally and financially devastating to patients, their families, and caretakers. Studies from animal models and cell cultures have shown that omega-3 fatty acids (n-3 FAs) are neuroprotective during development and aging. Numerous epidemiologic, postmortem, and clinical trials have been published on fish or n-3 FAs and Alzheimer's disease, dementia, or cognitive decline. Yet results across the literature in humans are inconsistent and thus difficult to interpret. This review provides background and context needed for interpretation of the findings, summaries of the literature grouped by longitudinal studies of fish, dietary n-3 FAs, blood levels of fatty acids, postmortem studies, and clinical trials, and subsequent interpretation of findings. Possible reasons for discrepancies in the literature are presented throughout, and conclusions suggest directions for future research. |
| | |
Authors:
|
Tina L Huang |
Related Documents
:
|
17406929 - N-3 polyunsaturated fatty acids and atopy in korean preschoolers. 18814829 - Omega-3 fatty acid supplementation for the prevention of arrhythmias. 20226839 - Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeosta... 3958799 - Dietary n-3 polyunsaturated fatty acids: modification of rat cardiac lipids and fatty a... 11857389 - N-3 and n-6 fatty acids in breast adipose tissue and relative risk of breast cancer in ... 9178549 - Effect of dietary n-3/n-6 fatty acid ratio on the total count, fatty acid composition, ... 16295849 - Role of organic acids in promoting colloidal transport of mercury from mine tailings. 3964339 - Fatty acid composition of serum cholesteryl esters in relation to serum lipids and apol... 6201199 - Single-channel studies on linear gramicidins with altered amino acid sequences. a compa... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of Alzheimer's disease : JAD Volume: 21 ISSN: 1875-8908 ISO Abbreviation: J. Alzheimers Dis. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-09-16 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 673-90 Citation Subset: IM |
Affiliation:
|
Rush University, Section of Nutrition and Nutritional Epidemiology, Chicago, IL, USA. tlhuang@uvic.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
blood,
diet therapy* Cognition Dietary Fats* Fatty Acids, Omega-3 / administration & dosage*, blood Humans |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebrovascular hypoperfusion induces spatial memory impairment, synaptic changes, and amyloid-? oli...
Next Document: Prediction of cognitive decline in healthy older adults using fMRI.