| Olsalazine in the treatment of active ulcerative colitis: a placebo controlled clinical trial and assessment of drug disposition. | |
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MedLine Citation:
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PMID: 3067339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy, safety and disposition of olsalazine was assessed in patients with left-sided ulcerative colitis or proctitis in a double-blind placebo controlled trial. Thirty patients with a mild-to-moderate attack of ulcerative colitis were randomly allocated to olsalazine capsules, 1 g b.d., or placebo for 6 weeks. Good clinical response was found in six patients receiving olsalazine and in two receiving placebo. Improvement in sigmoidoscopic findings and histological appearance of rectal biopsies was also seen more often in olsalazine-treated patients. Plasma concentrations of olsalazine were significantly higher in patients who improved. Olsalazine showed an advantage over placebo which needs to be confirmed by further studies; it was safe in sulphasalazine-sensitive patients but appeared to cause watery diarrhoea in two patients. |
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Authors:
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D J Hetzel; D J Shearman; J Labrooy; F Bochner; D M Imhoff; G E Gibson; R J Fitch; R Hecker; R Rowland |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 148 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-04-04 Completed Date: 1989-04-04 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 61-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Adelaide Hospital, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminosalicylic Acids
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adverse effects,
pharmacokinetics,
therapeutic use* Clinical Trials as Topic Colitis, Ulcerative / drug therapy* Double-Blind Method Drug Tolerance Female Humans Male Middle Aged Proctitis / drug therapy Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Aminosalicylic Acids; 15722-48-2/olsalazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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