Document Detail


Olsalazine in the treatment of active ulcerative colitis: a placebo controlled clinical trial and assessment of drug disposition.
MedLine Citation:
PMID:  3067339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy, safety and disposition of olsalazine was assessed in patients with left-sided ulcerative colitis or proctitis in a double-blind placebo controlled trial. Thirty patients with a mild-to-moderate attack of ulcerative colitis were randomly allocated to olsalazine capsules, 1 g b.d., or placebo for 6 weeks. Good clinical response was found in six patients receiving olsalazine and in two receiving placebo. Improvement in sigmoidoscopic findings and histological appearance of rectal biopsies was also seen more often in olsalazine-treated patients. Plasma concentrations of olsalazine were significantly higher in patients who improved. Olsalazine showed an advantage over placebo which needs to be confirmed by further studies; it was safe in sulphasalazine-sensitive patients but appeared to cause watery diarrhoea in two patients.
Authors:
D J Hetzel; D J Shearman; J Labrooy; F Bochner; D M Imhoff; G E Gibson; R J Fitch; R Hecker; R Rowland
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  148     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1988  
Date Detail:
Created Date:  1989-04-04     Completed Date:  1989-04-04     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  61-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Royal Adelaide Hospital, Australia.
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MeSH Terms
Descriptor/Qualifier:
Aminosalicylic Acids / adverse effects,  pharmacokinetics,  therapeutic use*
Clinical Trials as Topic
Colitis, Ulcerative / drug therapy*
Double-Blind Method
Drug Tolerance
Female
Humans
Male
Middle Aged
Proctitis / drug therapy
Random Allocation
Chemical
Reg. No./Substance:
0/Aminosalicylic Acids; 15722-48-2/olsalazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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