Document Detail


Olmesartan ameliorates myocardial function independent of blood pressure control in patients with mild-to-moderate hypertension.
MedLine Citation:
PMID:  19626403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensin II receptor blockers (ARBs) are suggested to be protective against myocardial hypertrophy and fibrosis, although such beneficial effects remain to be elucidated in the human heart. The aim of the present study was to examine the effect of a novel ARB, olmesartan, on myocardial function of the left ventricle in patients with mildto-moderate hypertension. We investigated 10 patients (6 men and 4 women, 62 +/- 7 years of age) who were stable with a single regimen of amlodipine, which was switched to olmesartan. Before and 8 months after changing medications, patients underwent echocardiographic examination and blood sampling, including measurement of the plasma high-sensitivity C-reactive protein (hsCRP) level. Peak velocities at the mitral annulus were determined by tissue Doppler imaging and used as measures of myocardial function. Olmesartan did not significantly alter blood pressure (BP) (systolic BP, 122 +/- 12 to 121 +/- 8 mmHg, P = 0.9; diastolic BP, 79 +/- 6 to 75 +/- 4 mmHg, P = 0.06) or parameters of global left ventricular systolic and diastolic function. Tissue Doppler imaging, however, revealed significant increases in the systolic (8.2 +/- 1.3 to 8.9 +/- 1.1 cm/s, P < 0.01) and early diastolic (6.7 +/- 0.9 to 7.6 +/- 1.0 cm/s, P = 0.02) velocities at the mitral annulus. This was associated with decreases in the left ventricular mass index (83 +/- 15 to 73 +/- 19 g/m2, P = 0.09) and hsCRP (683 +/- 555 to 655 +/- 450 ng/ml, P = 0.07). In conclusion, olmesartan improves myocardial function independent of BP reduction in hypertensive patients. Attenuated inflammatory changes as well as myocardial hypertrophy may play an important role.
Authors:
Rie Futai; Takahide Ito; Yasunori Kawanishi; Fumio Terasaki; Yasushi Kitaura
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-07-22
Journal Detail:
Title:  Heart and vessels     Volume:  24     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-23     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  294-300     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki, Osaka 569-8686, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Amlodipine / therapeutic use
Angiotensin II Type 1 Receptor Blockers / therapeutic use*
Biological Markers / blood
Blood Pressure / drug effects*
C-Reactive Protein / metabolism
Calcium Channel Blockers / therapeutic use
Echocardiography, Doppler, Color
Female
Fibrosis
Humans
Hypertension / drug therapy*,  physiopathology,  ultrasonography
Hypertrophy, Left Ventricular / drug therapy*,  physiopathology,  ultrasonography
Imidazoles / therapeutic use*
Inflammation / drug therapy,  physiopathology
Male
Middle Aged
Myocardium / pathology
Severity of Illness Index
Tetrazoles / therapeutic use*
Time Factors
Treatment Outcome
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Biological Markers; 0/Calcium Channel Blockers; 0/Imidazoles; 0/Tetrazoles; 0/olmesartan; 88150-42-9/Amlodipine; 9007-41-4/C-Reactive Protein

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