| Olive oil-provoked bile-dependent absorption of heparin from gastro-intestinal tract in rats. | |
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MedLine Citation:
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PMID: 4048247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aqueous heparin sodium solution dispersed in olive oil administered esophageally to fed rats induced blood plasma clearing activity, inhibition of blood coagulation and increased plasma heparin level. Plasma clearing activity was dependent on heparin dose (125 to 1000 mg/Kg). No plasma clearing activity being observed in pylorus- or coledoch-ligated rats, while heparin absorption reappeared after ox or rat bile administration, we conclude that olive oil favours enteral absorption of heparin by increasing bile function. |
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Authors:
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S Guarini; W Ferrari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacological research communications Volume: 17 ISSN: 0031-6989 ISO Abbreviation: Pharmacol Res Commun Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-11-21 Completed Date: 1985-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0236354 Medline TA: Pharmacol Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 685-97 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / physiology* Blood Coagulation / drug effects Dose-Response Relationship, Drug Emulsions Female Heparin / metabolism* Hydrogen-Ion Concentration Intestinal Absorption / drug effects* Oils / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Emulsions; 0/Oils; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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