| Olive oil, corn oil, and n-3 fatty acids differently affect lipids, lipoproteins, platelets, and superoxide formation in type II hypercholesterolemia. | |
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MedLine Citation:
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PMID: 1319109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate which dietary fat may provide the best response in terms of plasma lipids and lipoproteins and also of platelet aggregability and superoxide formation by white blood cells, 12 type II patients were randomly allocated to three different diets, which provided polyunsaturated fatty acids (corn oil), monounsaturated fatty acids (olive oil), and a supplementation of ethyl esters of n-3 fatty acids to a prudent diet. Olive oil and, more significantly, n-3 ethyl esters lowered total cholesterol best (-2.2% and -5.8%, respectively); the latter diet, as expected, also significantly lowered triglyceridemia (-21.4%). The corn-oil diet exerted a small, statistically significant reduction of high-density-lipoprotein cholesterol (HDL) (-4.3%), and it also lowered plasma total apo B concentrations (-3.8%). n-3 ethyl esters significantly raised both total (+3.1%) and particularly HDL2 cholesterol (+24%). Platelet reactivity was insignificantly reduced by the three regimens, but all three significantly reduced thrombin-stimulated formation of thromboxane B2. Finally, only the n-3 fatty acid supplementation significantly reduced O2- generation by adherent monocytes. Dietary unsaturated fatty acids are generally effective on the plasma lipid and lipoproteins in type II patients, but significant differences may be found between the three tested regimens. |
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Authors:
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C R Sirtori; E Gatti; E Tremoli; C Galli; G Gianfranceschi; G Franceschini; S Colli; P Maderna; F Marangoni; P Perego |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 56 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-07-23 Completed Date: 1992-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 113-22 Citation Subset: AIM; IM |
Affiliation:
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Center E Grossi Paoletti, University of Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins
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blood Blood Platelets / chemistry, metabolism Cholesterol / blood Corn Oil / therapeutic use* Dietary Fats, Unsaturated / therapeutic use* Fatty Acids / blood Fatty Acids, Omega-3 / therapeutic use* Female Humans Hypercholesterolemia / blood, diet therapy* Lipids / blood Lipoproteins / blood Male Monocytes / chemistry Neutrophils / chemistry Phospholipids / blood, chemistry Plant Oils / therapeutic use* Platelet Aggregation Random Allocation Superoxides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Lipids; 0/Lipoproteins; 0/Phospholipids; 0/Plant Oils; 11062-77-4/Superoxides; 57-88-5/Cholesterol; 8001-25-0/olive oil; 8001-30-7/Corn Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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