Document Detail


Oligosaccharide portion of GM1 enhances process formation by S20Y neuroblastoma cells.
MedLine Citation:
PMID:  3379408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The oligosaccharide portion of ganglioside GM1 was found to enhance neuritogenesis by S20Y murine neuroblastoma cells grown in vitro. The average length of the neurites produced by cells grown in the presence of the oligosaccharide portion of GM1 was comparable to that of cells grown in the presence of intact GM1. The processes of these cells were significantly longer (p less than 0.005, pooled t test) than those of cells grown in the presence of comparable concentrations of sialic acid, lactose, sialyllactose, GD1a, or the oligosaccharide moiety of GD1a. These results suggest that it is the oligosaccharide portion of GM1 that is responsible for the ability of GM1 to enhance process outgrowth by S20Y neuroblastoma cells.
Authors:
C L Schengrund; C Prouty
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  51     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-07-27     Completed Date:  1988-07-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
Affiliation:
Department of Biological Chemistry, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / pathology
Cholera Toxin / metabolism
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
G(M1) Ganglioside / analysis,  pharmacology*
Gangliosides / pharmacology
Mice
Neuroblastoma / pathology*
Oligosaccharides / isolation & purification,  pharmacology*
Resorcinols
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
AI 23721/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Gangliosides; 0/Oligosaccharides; 0/Resorcinols; 108-46-3/resorcinol; 12707-58-3/ganglioside, GD1a; 37758-47-7/G(M1) Ganglioside; 9012-63-9/Cholera Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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