| Oligopyrenotides: abiotic, polyanionic oligomers with nucleic acid-like structural properties. | |
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MedLine Citation:
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PMID: 20459110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oligopyrenotides, abiotic oligomers that exhibit significant structural analogies to the nucleic acids, are described. They are composed of achiral, phosphodiester-linked pyrene building blocks and a single chiral 1,2-diaminocyclohexane unit. These oligomers form stable hybrids in aqueous solution. Hybridization is based on stacking interactions of the pyrene building blocks. They show thermal denaturation/renaturation behavior that closely resembles DNA and RNA hybridization. In addition, oligopyrenotides display salt-concentration-dependent structural polymorphism. Thus, they possess a number of structural attributes that are typical of nucleic acids and therefore may serve as model systems for the design of artificial self-replicating systems. |
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Authors:
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Robert Häner; Florian Garo; Daniel Wenger; Vladimir L Malinovskii |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 132 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 7466-71 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland. robert.haener@ioc.unibe.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyclohexylamines
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chemistry* DNA / chemistry* Nucleic Acid Conformation Nucleic Acid Hybridization* Polymers / chemistry* Pyrenes / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexylamines; 0/Polymers; 0/Pyrenes; 0/polyanions; 129-00-0/pyrene; 694-83-7/1,2-cyclohexanediamine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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