Document Detail

Oligomeric Aβ-Induced Microglial Activation is Possibly Mediated by NADPH Oxidase.
MedLine Citation:
PMID:  23229789     Owner:  NLM     Status:  Publisher    
Recent studies have shown that oligomeric amyloid-β (oAβ) peptide can potentially activate microglia in addition to inducing more potent neurotoxicity compared with fibrillar Aβ (fAβ); however, its mechanisms of action remain unclear. This study was designed to investigate the possible mechanisms involved in the microglial activation induced by oAβ in BV-2 microglial cells. The results showed that oAβ induced activated properties of microglia, including higher proliferative capacity as well as increased production of reactive oxygen species, nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). NADPH oxidase inhibitors [diphenylene iodonium (DPI) and apocynin (4-hydroxy-3-methoxy-acetophenone)] prevented the microglial activation induced by oAβ, suggesting that NADPH oxidase activation was involved in microglial activation. In addition, TNF-α and IL-1β, which are massively released by activated microglia, significantly induced the activation of microglia, thereby resulting in the production of NO and proliferation of microglia, respectively. These effects could be inhibited by diphenylene iodonium and apocynin, indicating a self-cycle regulated by NADPH oxidase in microglial activation in response to oAβ. In conclusion, microglial activation induced by oAβ is possibly mediated by NADPH oxidase, suggesting that oAβ, which is normally considered a neurotoxin, may also lead to indirect neuronal damage through the pro-inflammation activation of microglia in Alzheimer's disease and that NADPH oxidase could be a potential target to prevent oAβ-induced inflammatory neurodegeneration.
Juan Li; Jing Yu Yang; Xue Chun Yao; Xue Xue; Qing Chun Zhang; Xiao Xiao Wang; Ling Ling Ding; Chun Fu Wu
Related Documents :
21555119 - Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide sy...
24224909 - The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting er-relat...
24064719 - Update on staphylococcal superantigen-induced signaling pathways and therapeutic interv...
23539679 - Scolopendra subspinipes mutilans protected the cerulein-induced acute pancreatitis by i...
24919149 - Innate immune sensing of bacterial modifications of rho gtpases by the pyrin inflammasome.
23949769 - Mesenchymal cells hold the key to immune cell recruitment to and migration within melan...
19289509 - Yersinia pestis can reside in autophagosomes and avoid xenophagy in murine macrophages ...
16797629 - Green tea polyphenols-induced apoptosis in human osteosarcoma saos-2 cells involves a c...
8045259 - C-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-11
Journal Detail:
Title:  Neurochemical research     Volume:  -     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Box 31, Shenyang, 110016, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessment of the correlation between TIMP4 SNPs and schizophrenia and autism spectrum disorders.
Next Document:  Comparison and effects of acute lamotrigine treatment on extracellular excitatory amino acids in the...