Document Detail

Oligohydramnios and pulmonary hypoplasia: a case in which involvement of an angiotensin II receptor antagonist was suspected.
MedLine Citation:
PMID:  18412789     Owner:  NLM     Status:  MEDLINE    
Administration of an angiotensin II receptor antagonist (ARB) during the second trimester of pregnancy is known to cause irreversible renal damage in the fetus. We report a case in which ARB was given to the mother from the first trimester until 26 weeks' gestation. The patient had diabetic nephropathy with accompanying nephrotic syndrome. At 8 weeks' gestation, she was started on candesartan cilexetil (an ARB). At 26 weeks' gestation, she was transferred to our center. Severe oligohydramnios was noted. The pregnancy was terminated, and she delivered at 27 weeks' gestation. The neonate weighed 884 g and died 1 h after birth. Autopsy revealed that the lung/bodyweight ratio was 0.0096 (>0.015) and pulmonary hypoplasia was noted. Histological examination of the kidneys showed tubular dysgenesis with poor differentiation of the proximal tubules.
Kaoru Kato; Mika Okuda; Hiroshi Ishikawa; Tsuneo Takahashi; Fumiki Hirahara
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  34     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-16     Completed Date:  2008-10-07     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  242-6     Citation Subset:  IM    
Maternity and Neonate Center, Yokohama City University Medical Center, Urafune-cho, Minami-ku, Yokohama, Kanagawa, Japan.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / adverse effects*,  therapeutic use
Benzimidazoles / adverse effects*,  therapeutic use
Biphenyl Compounds / adverse effects*,  therapeutic use
Diabetic Nephropathies / pathology
Fatal Outcome
Hypertension / drug therapy
Infant, Newborn
Lung / pathology*
Oligohydramnios / chemically induced*,  pathology
Pregnancy in Diabetics / pathology
Tetrazoles / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Benzimidazoles; 0/Biphenyl Compounds; 0/Tetrazoles; R85M2X0D68/candesartan cilexetil

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