Document Detail

Oligodendroglioma arising in the glial component of ovarian teratomas: a series of six cases and review of literature.
MedLine Citation:
PMID:  22496515     Owner:  NLM     Status:  Publisher    
AimsTo report the exceedingly rare occurrence of oligodendroglioma in the glial component of ovarian teratomas.MethodsSix cases of oligodendrogliomas arising in the glial component of ovarian teratomas were studied and the literature was reviewed. Immunohistochemistry was performed by the Flex technique.ResultsThe ages of the patients ranged from 12 to 28 years (mean 21 years). Four tumours were located in the right and one in the left ovary. The size of the ovarian cysts ranged from 7 cm to 29 cm (mean 19.6 cm). Four cases arose in immature and two cases in mature teratomas. In all cases, oligodendroglioma was WHO grade II. On immunohistochemistry, glial fibrillary acidic protein stain was positive in all cases. The Mib 1 (Ki 67) proliferative index was low and the tumour cells were negative for synaptophysin. Follow-up was available in five patients and ranged from 1 to 42 months. Two patients died of disease after 1 and 36 months of diagnosis, respectively. In both these cases oligodendroglioma arose in an immature teratoma. The remaining three patients are alive with a follow-up of 4-42 months.ConclusionsOligodendroglioma arising in the glial component of ovarian teratomas is exceedingly rare. Ovarian teratomas should be extensively sampled and carefully evaluated to rule out the possibility of a glial tumour. This is the single and largest series of oligodendrogliomas arising in ovarian teratomas. The prognosis is good for oligodendrogliomas arising in mature teratomas compared with those arising in immature teratomas, although long-term follow-up is needed to determine the exact behaviour.
Nasir Ud Din; Aisha Memon; Kanwal Aftab; Zubair Ahmad; Rashida Ahmed; Sheema Hassan
Related Documents :
25161135 - Ebstein anomaly: a review.
3574885 - Angioid streaks associated with pseudoxanthoma elasticum in a 13-year-old patient.
16231535 - Tension pneumothorax complicated by double-lumen endotracheal tube intubation.
21590475 - Squamous cell carcinoma in the larynx in a 7-year-child.
1562955 - You drive me crazy: a case report of acute psychosis and neurocysticercosis.
15863595 - Symptomatic cecal perforation by an intrauterine device with appendectomy removal.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-11
Journal Detail:
Title:  Journal of clinical pathology     Volume:  -     ISSN:  1472-4146     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cancers related to viral agents that have a direct role in carcinogenesis: pathological and diagnost...
Next Document:  Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource.