| Oligodendroglial dysplasia in two bullmastiff dogs. | |
| | |
MedLine Citation:
|
PMID: 16407484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Leukodystrophies are inherited neurological disorders involving central nervous system white matter. They are uncommon in animals but a few, breed-specific entities have been described. In 2002, two young-adult, purebred Bullmastiff dogs from central New York State presented to their referring veterinarians displaying moderate to severe ataxia of all limbs, spastic tetraparesis that was worse in the pelvic limbs, and a diffuse, action-related, whole-body tremor. Clinical signs were insidious in onset and slowly progressive. Anatomic diagnoses considered were a C1-C5 lesion or, based on the whole-body tremor, a diffuse central nervous system disorder. No gross lesions were apparent in the brain or spinal cord. Histopathologically, numerous, multifocal, sharply demarcated, small, ovoid to angular areas of myelin pallor (plaques) were present throughout the major white matter tracts of the brainstem and spinal cord. These plaques, which often were traversed by axons, did not stain with luxol fast blue for myelin and were associated with minimal astrocytosis. Ultrastructural findings include occasional hypertrophic glia in white matter, rare unmyelinated segments of axons, and focal proliferation of tubule-containing cytoplasmic glial cell processes (oligodendroglial). The described clinical and morphological findings and age of onset are similar to the well-characterized, presumably hereditary, bovine syndrome known as Charolais ataxia or oligodendroglial dysplasia. This article presents the first description of a leukodystrophy in the Bullmastiff breed and the first report of oligodendroglial dysplasia in animals other than Charolais cattle. |
| | |
Authors:
|
J P Morrison; S J Schatzberg; A De Lahunta; J T Ross; P Bookbinder; B A Summers |
Related Documents
:
|
7944274 - Masson's hemangioma of spinal meninges causing cord compression with paraplegia. 7622704 - Unusual long-standing gd-dtpa enhancement in a chronic progressive myelopathy. 8115174 - Synovial cyst of dens causing spinal cord compression. case report. 21160674 - Endoscopic approach for diagnosing autoimmune pancreatitis. 18431554 - Intradiploic cavernous hemangioma of the skull in a child: a case report. 22845844 - Sarcoidosis - a clinically orientated review. |
Publication Detail:
|
Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
|
Title: Veterinary pathology Volume: 43 ISSN: 0300-9858 ISO Abbreviation: Vet. Pathol. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2006-01-12 Completed Date: 2006-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 29-35 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dog Diseases / pathology* Dogs Fatal Outcome Hereditary Central Nervous System Demyelinating Diseases / pathology, veterinary* Immunohistochemistry / veterinary Male Microscopy, Electron, Transmission / veterinary Oligodendroglia / ultrastructure* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Feline large granular lymphocyte (LGL) lymphoma with secondary leukemia: primary intestinal origin w...
Next Document: Expression of terminal differentiation proteins defines stages of mouse mammary gland development.