Document Detail

Oligoclonal free light chains in cerebrospinal fluid as markers of intrathecal inflammation. Comparison with oligoclonal IgG.
MedLine Citation:
PMID:  25485529     Owner:  NLM     Status:  Publisher    
AIMS: To compare the sensitivity and specificity of CSF-restricted oligoclonal IgG and free light chains as markers of multiple sclerosis and other inflammatory neurological diseases.
METHODS: 196 paired CSF and serum samples were examined for oligoclonal IgG and oligoclonal free light chains. The sensitivity and specificity of the tests were calculated and optimal cut-offs for the number of CSF-restricted oligoclonal bands were then determined by analysis of receiver operating characteristic curves.
RESULTS: Optimal cut-off values were ≥5 IgG bands for multiple sclerosis, ≥4 IgG bands for inflammatory neurological disease, ≥6 free κ, and ≥2 free λ bands for both purposes. Using these cut-off values, sensitivities and specificities for multiple sclerosis were 83.8% and 91.3% for IgG, 83.8% and 81.0% for free κ, and 67.6% and 75.4% for free λ. For inflammatory neurological disease, sensitivities and specificities were 60.8% and 95.7% for IgG, 69.6% and 92.6% for free κ, and 64.8% and 86.2% for free λ.
CONCLUSIONS: Although exact cut-off values may vary according to method, reporting borderline results as positive, may compromise the specificity of the test and should be avoided.. The detection of intrathecal free light chain synthesis may be of value especially when the oligoclonal IgG test is negative or borderline, even though its specificity is slightly lower.
David Zeman; Pavel Hradilek; Pavlina Kusnierova; Radim Piza; Katarina Reguliova; Ivana Woznicova; Olga Zapletalova
Related Documents :
25485529 - Oligoclonal free light chains in cerebrospinal fluid as markers of intrathecal inflamma...
15013499 - Reproducibility of electromyography and ground reaction force during various running te...
21671739 - Neural correlates of subsecond time distortion in the middle temporal area of visual co...
19470699 - Vastus lateralis single motor unit emg at the same absolute torque production at differ...
7042199 - Emg-force relationships in skeletal muscle.
21562259 - Left parietal regions are critical for adaptive visuomotor control.
16662799 - Effect of photosynthetic inhibitors and uncouplers of oxidative phosphorylation on nitr...
16811599 - Maintenance and suppression of responding under schedules of electric shock presentation.
1166769 - An evoked response study of the first-order difference tone in man.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-5
Journal Detail:
Title:  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia     Volume:  -     ISSN:  1213-8118     ISO Abbreviation:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-8     Completed Date:  -     Revised Date:  2014-12-9    
Medline Journal Info:
Nlm Unique ID:  101140142     Medline TA:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of brain vessel imaging from transtemporal and transcondylar approaches using contrast-en...
Next Document:  The prevalence of non organ specific and thyroid autoimmunity in patients with polycystic ovary synd...